Significant expression of CHK1 and p53 in bladder urothelial carcinoma as potential therapeutic targets and prognosis

  • Authors:
    • Linfeng Zheng
    • Yuping Zhu
    • Lei Lei
    • Wenyong Sun
    • Guoping Cheng
    • Shifeng Yang
  • View Affiliations

  • Published online on: November 3, 2017     https://doi.org/10.3892/ol.2017.7344
  • Pages:568-574
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Abstract

Checkpoint kinase 1 (CHK1) and p53 are involved in cell‑cycle checkpoint, and cellular response to DNA damage. CHK1 and p53 are overexpressed in bladder urothelial carcinoma (BUC); however, a clear elucidation on their interaction and influence in the progress of BUC is absent. The aim of the present study was to examine the correlation between CHK1 and p53 in BUC, and analyze their value as therapeutic targets and prognostic indicators in BUC. A clinically annotated cohort of 110 patients with BUC was identified retrospectively. EnVision‑based immunohistochemistry and western blot analysis of the aforementioned DNA repair proteins were conducted on formalin‑fixed‑paraffin‑embedded or frozen tissues from the primary tumor. A total of 45 peritumoral tissue cases were assessed similarly as the control group. In the cohort of 110 patients with BUC, a significant overexpression of CHK1 and p53 was observed in primary compared with the peritumoral tissues (P<0.05). CHK1 and p53 demonstrated a positive correlation in BUC, and both were positively associated with the histological grade, clinical pathological staging, lymphatic metastasis and the 5‑year survival rate (P<0.05). However, CHK1 and p53 were not associated with sex, age, tumor diameter, single/multiple sites or incipient/recurrence. The overexpression of CHK1 and p53, and their synergistic interaction were putatively correlated with the physiology of BUC that may be deemed as potential therapeutic targets and prognostic indicators.

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January 2018
Volume 15 Issue 1

Print ISSN: 1792-1074
Online ISSN:1792-1082

2016 Impact Factor: 1.39
Ranked #68/217 Oncology
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APA
Zheng, L., Zhu, Y., Lei, L., Sun, W., Cheng, G., & Yang, S. (2018). Significant expression of CHK1 and p53 in bladder urothelial carcinoma as potential therapeutic targets and prognosis. Oncology Letters, 15, 568-574. https://doi.org/10.3892/ol.2017.7344
MLA
Zheng, L., Zhu, Y., Lei, L., Sun, W., Cheng, G., Yang, S."Significant expression of CHK1 and p53 in bladder urothelial carcinoma as potential therapeutic targets and prognosis". Oncology Letters 15.1 (2018): 568-574.
Chicago
Zheng, L., Zhu, Y., Lei, L., Sun, W., Cheng, G., Yang, S."Significant expression of CHK1 and p53 in bladder urothelial carcinoma as potential therapeutic targets and prognosis". Oncology Letters 15, no. 1 (2018): 568-574. https://doi.org/10.3892/ol.2017.7344