Open Access

Effects of miR-21 on proliferation and apoptosis in human gastric adenocarcinoma cells

  • Authors:
    • Jun-Bao Gu
    • Xue-Bin Bao
    • Zhao Ma
  • View Affiliations

  • Published online on: May 15, 2017     https://doi.org/10.3892/ol.2017.6171
  • Pages:618-622
  • Copyright: © Gu et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

The present study investigated the expression of miR-21 in MGC803 gastric cancer cells and its effects on Bcl-2 expression and cell proliferation, apoptosis, and invasion. In total 50 patients were recruited with gastric cancer who were admitted to the Henan Province People's Hospital. The samples of gastric cancer and the adjacent normal tissues were collected after surgery. We found that mRNA levels of miR-21 and Bcl-2 were significantly elevated in tumor tissues compared to control tissue. The expression of Bcl-2 protein was also elevated in cancerous tissue. This high expression of Bcl-2 was associated with clinical stage, lymph node metastasis, and tumor differentiation degree. Inhibition of miR-21 reduced the levels of miR-21 and Bcl-2 in MGC803 cells, and lowered cell proliferation and invasiveness. These results indicate that miR-21 and Bcl-2 may participate in the occurrence and development of gastric adenocarcinoma, suggesting their potential role as biomarkers and therapeutic targets.

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Journal Cover

January 2018
Volume 15 Issue 1

Print ISSN: 1792-1074
Online ISSN:1792-1082

2016 Impact Factor: 1.39
Ranked #68/217 Oncology
(total number of cites)

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APA
Gu, J., Bao, X., & Ma, Z. (2018). Effects of miR-21 on proliferation and apoptosis in human gastric adenocarcinoma cells. Oncology Letters, 15, 618-622. https://doi.org/10.3892/ol.2017.6171
MLA
Gu, J., Bao, X., Ma, Z."Effects of miR-21 on proliferation and apoptosis in human gastric adenocarcinoma cells". Oncology Letters 15.1 (2018): 618-622.
Chicago
Gu, J., Bao, X., Ma, Z."Effects of miR-21 on proliferation and apoptosis in human gastric adenocarcinoma cells". Oncology Letters 15, no. 1 (2018): 618-622. https://doi.org/10.3892/ol.2017.6171