Open Access

Human leukocyte antigen‑G expression and polymorphisms promote cancer development and guide cancer diagnosis/treatment (Review)

  • Authors:
    • Yanwen Zhang
    • Shuwen Yu
    • Yali Han
    • Yunshan Wang
    • Yuping Sun
  • View Affiliations

  • Published online on: November 14, 2017     https://doi.org/10.3892/ol.2017.7407
  • Pages:699-709
  • Copyright: © Zhang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Human leukocyte antigen‑G (HLA‑G) is a non‑classical HLA molecule, predominantly expressed in cytotrophoblast cells to protect the fetus during pregnancy. Notably, a high frequency of HLA‑G expression has been observed in a wide variety of cancer types in previous studies. Furthermore, HLA‑G expression in cancer has been considered to be detrimental, since it can protect cancer cells from natural killer cell cytotoxic T lymphocyte‑mediated destruction, promote tumor spreading and shorten the survival time of patients by facilitating tumor immune evasion. In addition, HLA‑G polymorphisms have been investigated in numerous types of cancer and are considered as risk factors and predictive markers of cancer. This review focuses on HLA‑G expression and its polymorphisms in cancer, analyzing the mechanisms of HLA‑G in promoting cancer development, and evaluating the potential and value of its clinical application as a diagnostic and prognostic biomarker, or even as a prospective therapeutic target in certain types of tumors.

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January 2018
Volume 15 Issue 1

Print ISSN: 1792-1074
Online ISSN:1792-1082

2016 Impact Factor: 1.39
Ranked #68/217 Oncology
(total number of cites)

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APA
Zhang, Y., Yu, S., Han, Y., Wang, Y., & Sun, Y. (2018). Human leukocyte antigen‑G expression and polymorphisms promote cancer development and guide cancer diagnosis/treatment (Review). Oncology Letters, 15, 699-709. https://doi.org/10.3892/ol.2017.7407
MLA
Zhang, Y., Yu, S., Han, Y., Wang, Y., Sun, Y."Human leukocyte antigen‑G expression and polymorphisms promote cancer development and guide cancer diagnosis/treatment (Review)". Oncology Letters 15.1 (2018): 699-709.
Chicago
Zhang, Y., Yu, S., Han, Y., Wang, Y., Sun, Y."Human leukocyte antigen‑G expression and polymorphisms promote cancer development and guide cancer diagnosis/treatment (Review)". Oncology Letters 15, no. 1 (2018): 699-709. https://doi.org/10.3892/ol.2017.7407