Open Access

Effects of liver cirrhosis on portal vein embolization prior to right hepatectomy in patients with primary liver cancer

  • Authors:
    • Jun‑Hui Sun
    • Yue‑Lin Zhang
    • Chun‑Hui Nie
    • Ju Li
    • Tan‑Yang Zhou
    • Guan‑Hui Zhou
    • Tong‑Yin Zhu
    • Li‑Ming Chen
    • Wei‑Lin Wang
    • Shu‑Sen Zheng
  • View Affiliations

  • Published online on: December 5, 2017     https://doi.org/10.3892/ol.2017.7530
  • Pages:1411-1416
  • Copyright: © Sun et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Preoperative portal vein embolization (PVE) induces compensatory hyperplasia of the future liver remnants (FLR), thus increasing resectability in the non‑cirrhotic patients with primary liver cancer (PLC). However, it is unclear if it is similar in patients with liver cirrhosis. Therefore, the present study investigated the PVE value prior to liver resection in patients with PLC, and the liver cirrhotic effects on the compensatory hypertrophy of FLRs following PVE. In the present study, 21 patients with PLC who successfully underwent hepatic resection subsequent to PVE, were retrospectively examined. The patients were divided into a non‑cirrhosis group and a cirrhosis group according to the absence or presence of cirrhosis, respectively. The FLR volume between the two groups of patients was compared. There was a significant difference in the FLR volume for all patients prior to, and 4‑6 weeks following, PVE (P<0.001). PVE induced significant compensatory hypertrophy in the FLRs whether in the non‑cirrhosis group (P=0.002) or cirrhosis group (P<0.001). However, no significant difference was identified between the two groups with respect to FLR volume enlargement 4‑6 weeks following PVE (P=0.373). In conclusion, PVE prior to hepatectomy may promote FLR compensatory hypertrophy and an increase in the resectability of PLC tumors. No significant effects of liver cirrhosis were identified on liver lobe hyperplasia following PVE.

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February 2018
Volume 15 Issue 2

Print ISSN: 1792-1074
Online ISSN:1792-1082

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Copy and paste a formatted citation
APA
Sun, J., Zhang, Y., Nie, C., Li, J., Zhou, T., Zhou, G. ... Zheng, S. (2018). Effects of liver cirrhosis on portal vein embolization prior to right hepatectomy in patients with primary liver cancer. Oncology Letters, 15, 1411-1416. https://doi.org/10.3892/ol.2017.7530
MLA
Sun, J., Zhang, Y., Nie, C., Li, J., Zhou, T., Zhou, G., Zhu, T., Chen, L., Wang, W., Zheng, S."Effects of liver cirrhosis on portal vein embolization prior to right hepatectomy in patients with primary liver cancer". Oncology Letters 15.2 (2018): 1411-1416.
Chicago
Sun, J., Zhang, Y., Nie, C., Li, J., Zhou, T., Zhou, G., Zhu, T., Chen, L., Wang, W., Zheng, S."Effects of liver cirrhosis on portal vein embolization prior to right hepatectomy in patients with primary liver cancer". Oncology Letters 15, no. 2 (2018): 1411-1416. https://doi.org/10.3892/ol.2017.7530