Open Access

Effect of matrine against breast cancer by downregulating the vascular endothelial growth factor via the Wnt/β‑catenin pathway

  • Authors:
    • Xu Xiao
    • Man Ao
    • Fan Xu
    • Xiao Li
    • Jiuli Hu
    • Ying Wang
    • Daixiao Li
    • Xiaoqin Zhu
    • Chunlan Xin
    • Wenda Shi
  • View Affiliations

  • Published online on: December 5, 2017     https://doi.org/10.3892/ol.2017.7519
  • Pages: 1691-1697
  • Copyright: © Xiao et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

The aim of the present study was to investigate the effect of matrine on breast cancer and its underlying mechanism. Matrine is a major component of Sophora flavescens, exhibited antitumor activity in a number of neoplasms, including breast cancer. The present study revealed that matrine inhibited cell viability and induced apoptosis in 4T1 and MCF‑7 cells in a dose‑ and time‑dependent manner in vitro. In addition, matrine suppressed the 4T1‑tumor growth, induced apoptosis, inhibited the expression of vascular endothelial growth factor and downregulated the Wnt/β‑catenin signaling pathway in vivo. All these findings indicated that matrine may be a novel effective candidate for the treatment of breast cancer.

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February 2018
Volume 15 Issue 2

Print ISSN: 1792-1074
Online ISSN:1792-1082

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APA
Xiao, X., Ao, M., Xu, F., Li, X., Hu, J., Wang, Y. ... Shi, W. (2018). Effect of matrine against breast cancer by downregulating the vascular endothelial growth factor via the Wnt/β‑catenin pathway. Oncology Letters, 15, 1691-1697. https://doi.org/10.3892/ol.2017.7519
MLA
Xiao, X., Ao, M., Xu, F., Li, X., Hu, J., Wang, Y., Li, D., Zhu, X., Xin, C., Shi, W."Effect of matrine against breast cancer by downregulating the vascular endothelial growth factor via the Wnt/β‑catenin pathway". Oncology Letters 15.2 (2018): 1691-1697.
Chicago
Xiao, X., Ao, M., Xu, F., Li, X., Hu, J., Wang, Y., Li, D., Zhu, X., Xin, C., Shi, W."Effect of matrine against breast cancer by downregulating the vascular endothelial growth factor via the Wnt/β‑catenin pathway". Oncology Letters 15, no. 2 (2018): 1691-1697. https://doi.org/10.3892/ol.2017.7519