Licochalcone A inhibits PI3K/Akt/mTOR signaling pathway activation and promotes autophagy in breast cancer cells

  • Authors:
    • Lei Xue
    • Wei‑Jie Zhang
    • Qing‑Xia Fan
    • Liu‑Xing Wang
  • View Affiliations

  • Published online on: November 21, 2017     https://doi.org/10.3892/ol.2017.7451
  • Pages: 1869-1873
Metrics: HTML 0 views | PDF 0 views     Cited By (CrossRef): 0 citations

Abstract

Previous studies have demonstrated that Licochalcone A possesses anti‑inflammatory, anticancer, anti‑bacterial, anti‑malarial and anti‑parasitic activities. In the present study the potential anticancer effects of Licochalcone A on MCF‑7 cells were investigated. Licochalcone A significantly decreased cell viability and promoted autophagy and apoptosis, as demonstrated by an MTT assay, acridine orange staining and Annexin V‑fluorescein isothiocyanate staining, respectively. Western blot analyses demonstrated that Licochalcone A treatment activated the LC3‑II signaling pathway while suppressing the phosphoinositide 3‑kinase (PI3K)/RAC‑α serine‑threonine‑protein kinase (Akt)/mammalian target of rapamycin (mTOR) signaling pathway. In addition, Licochalcone A significantly increased caspase‑3 activity and significantly decreased B‑cell lymphoma‑2 expression. The results from the present study indicate that Licochalcone A inhibits PI3K/Akt/mTOR activation, and promotes autophagy and apoptosis in MCF‑7 cells.

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February 2018
Volume 15 Issue 2

Print ISSN: 1792-1074
Online ISSN:1792-1082

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APA
Xue, L., Zhang, W., Fan, Q., & Wang, L. (2018). Licochalcone A inhibits PI3K/Akt/mTOR signaling pathway activation and promotes autophagy in breast cancer cells. Oncology Letters, 15, 1869-1873. https://doi.org/10.3892/ol.2017.7451
MLA
Xue, L., Zhang, W., Fan, Q., Wang, L."Licochalcone A inhibits PI3K/Akt/mTOR signaling pathway activation and promotes autophagy in breast cancer cells". Oncology Letters 15.2 (2018): 1869-1873.
Chicago
Xue, L., Zhang, W., Fan, Q., Wang, L."Licochalcone A inhibits PI3K/Akt/mTOR signaling pathway activation and promotes autophagy in breast cancer cells". Oncology Letters 15, no. 2 (2018): 1869-1873. https://doi.org/10.3892/ol.2017.7451