Dihydroartemisinin increases apoptosis of colon cancer cells through targeting Janus kinase 2/signal transducer and activator of transcription 3 signaling

  • Authors:
    • Dongsheng Wang
    • Bei Zhong
    • Yu Li
    • Xiaodong Liu
  • View Affiliations

  • Published online on: November 29, 2017     https://doi.org/10.3892/ol.2017.7502
  • Pages:1949-1954
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Abstract

As a derivative of artemisinin, dihydroartemisinin is effective in the treatment of malaria. Dihydroartemisinin has been identified to possess inhibitory effects in numerous types of animal model with tumors, indicating that it has an antineoplastic effect. The aim of the present study was to analyze the potential anticancer effects of dihydroartemisinin, particularly its effect on apoptosis of colon cancer cells. In the present study, it was identified that dihydroartemisinin inhibited cell viability, promoted cell apoptosis, increased B‑cell lymphoma‑2‑associated X‑protein expression, increased caspase‑3/9 activities, decreased poly(ADP‑ribose) polymerase levels, decreased phosphorylation of extracellular‑signal‑regulated kinase, and increased phosphorylation of c‑Jun N‑terminal kinase and p38 mitogen‑activated protein kinase in colon cancer cells. Conversely, the phosphorylation of Janus kinase 2 (JAK2) and signal transducer and activator of transcription 3 (STAT3) was suppressed by dihydroartemisinin in colon cancer cells. These results demonstrate that the potential anticancer effects of dihydroartemisinin may increase apoptosis of colon cancer cells through targeting JAK2/STAT3 signaling.

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February 2018
Volume 15 Issue 2

Print ISSN: 1792-1074
Online ISSN:1792-1082

2016 Impact Factor: 1.39
Ranked #68/217 Oncology
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APA
Wang, D., Zhong, B., Li, Y., & Liu, X. (2018). Dihydroartemisinin increases apoptosis of colon cancer cells through targeting Janus kinase 2/signal transducer and activator of transcription 3 signaling. Oncology Letters, 15, 1949-1954. https://doi.org/10.3892/ol.2017.7502
MLA
Wang, D., Zhong, B., Li, Y., Liu, X."Dihydroartemisinin increases apoptosis of colon cancer cells through targeting Janus kinase 2/signal transducer and activator of transcription 3 signaling". Oncology Letters 15.2 (2018): 1949-1954.
Chicago
Wang, D., Zhong, B., Li, Y., Liu, X."Dihydroartemisinin increases apoptosis of colon cancer cells through targeting Janus kinase 2/signal transducer and activator of transcription 3 signaling". Oncology Letters 15, no. 2 (2018): 1949-1954. https://doi.org/10.3892/ol.2017.7502