Open Access

β‑catenin, leucine-rich repeat-containing G protein-coupled receptor 5 and GATA-binding factor 6 are associated with the normal mucosa‑adenoma‑adenocarcinoma sequence of colorectal tumorigenesis

  • Authors:
    • Bin Yang
    • Liang Mao
    • Yan Li
    • Qia Li
    • Xioli Li
    • Yunjing Zhang
    • Zhenhua Zhai
  • View Affiliations

  • Published online on: December 8, 2017     https://doi.org/10.3892/ol.2017.7566
  • Pages: 2287-2295
  • Copyright: © Yang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

In the present study, the expression of β-catenin, leucine-rich repeat-containing G protein‑coupled receptor 5 (LGR5) and GATA6 was investigated during the transition from normal mucosa through to adenoma and adenocarcinoma in colorectal tissue sections obtained from 65 patients with a pathological diagnosis of colorectal adenocarcinoma and a history of adenoma. Immunohistochemical staining of β‑catenin, LGR5 and GATA6 was performed and evaluated. The nuclear expression of β‑catenin and the cytoplasmic expression of LGR5 and GATA6 were increased in samples as they progressed from normal mucosa to adenoma and adenocarcinoma. However, membrane‑bound β‑catenin and nuclear GATA6 expression decreased. Positive correlations were observed between the expression of LGR5 and cytoplasmic GATA6 in adenoma (P=0.0005; rs=0.48) and adenocarcinoma samples (P=0.007; rs=0.38): However, no significant association was observed in normal mucosa (P=0.399). The expression of nuclear β‑catenin was significantly increased in the serosal layer compared with the invasive layers of the colorectal wall in samples of adenocarcinoma (P=0.042). The results of the present study suggest that the nuclear expression of β‑catenin and LGR5 and the cytoplasmic expression of GATA6 function together during the development of colorectal carcinoma.

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February 2018
Volume 15 Issue 2

Print ISSN: 1792-1074
Online ISSN:1792-1082

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APA
Yang, B., Mao, L., Li, Y., Li, Q., Li, X., Zhang, Y., & Zhai, Z. (2018). β‑catenin, leucine-rich repeat-containing G protein-coupled receptor 5 and GATA-binding factor 6 are associated with the normal mucosa‑adenoma‑adenocarcinoma sequence of colorectal tumorigenesis. Oncology Letters, 15, 2287-2295. https://doi.org/10.3892/ol.2017.7566
MLA
Yang, B., Mao, L., Li, Y., Li, Q., Li, X., Zhang, Y., Zhai, Z."β‑catenin, leucine-rich repeat-containing G protein-coupled receptor 5 and GATA-binding factor 6 are associated with the normal mucosa‑adenoma‑adenocarcinoma sequence of colorectal tumorigenesis". Oncology Letters 15.2 (2018): 2287-2295.
Chicago
Yang, B., Mao, L., Li, Y., Li, Q., Li, X., Zhang, Y., Zhai, Z."β‑catenin, leucine-rich repeat-containing G protein-coupled receptor 5 and GATA-binding factor 6 are associated with the normal mucosa‑adenoma‑adenocarcinoma sequence of colorectal tumorigenesis". Oncology Letters 15, no. 2 (2018): 2287-2295. https://doi.org/10.3892/ol.2017.7566