Open Access

Paclitaxel-induced hypothermia and hypoperfusion increase breast cancer metastasis and angiogenesis in mice

  • Authors:
    • Nozomi Ami
    • Hideki Sato
    • Yoshihiro Hayakawa
  • View Affiliations

  • Published online on: December 14, 2017     https://doi.org/10.3892/ol.2017.7621
  • Pages: 2330-2334
  • Copyright: © Ami et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Housing temperature has been shown to influence thermoregulation and behavior of preclinical cancer models; and anti‑cancer drugs typically reduce peripheral blood flow and body temperature. In the present study, the effects of paclitaxel (PTX)‑induced reduction of body temperature and peripheral blood flow on metastatic 4T1 breast cancer was investigated in a mouse model and the modification of these effects by thermoneutral temperature was also assessed. A single dose of PTX decreased the body temperature and peripheral blood flow in mice housed at a standard temperature (23˚C). Furthermore, although lung metastasis and angiogenesis of inoculated 4T1 cells increased in mice pretreated with PTX, mice housed at a thermoneutral temperature (30˚C) could compensate their body temperature and peripheral blood flow compared with control mice, and also suppressed 4T1 angiogenesis and metastasis to lung. The present results imply that maintenance of body temperature or efficient energy supply for thermogenesis may prevent tumor relapse or metastasis after chemotherapy.

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February 2018
Volume 15 Issue 2

Print ISSN: 1792-1074
Online ISSN:1792-1082

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APA
Ami, N., Sato, H., & Hayakawa, Y. (2018). Paclitaxel-induced hypothermia and hypoperfusion increase breast cancer metastasis and angiogenesis in mice. Oncology Letters, 15, 2330-2334. https://doi.org/10.3892/ol.2017.7621
MLA
Ami, N., Sato, H., Hayakawa, Y."Paclitaxel-induced hypothermia and hypoperfusion increase breast cancer metastasis and angiogenesis in mice". Oncology Letters 15.2 (2018): 2330-2334.
Chicago
Ami, N., Sato, H., Hayakawa, Y."Paclitaxel-induced hypothermia and hypoperfusion increase breast cancer metastasis and angiogenesis in mice". Oncology Letters 15, no. 2 (2018): 2330-2334. https://doi.org/10.3892/ol.2017.7621