Prediction of long‑term survival rates in patients undergoing curative resection for solitary hepatocellular carcinoma

  • Authors:
    • Yi Cao
    • Zhelong Jiang
    • Shaohu Wang
    • Haoyang Zhang
    • Yi Jiang
    • Lizhi Lv
  • View Affiliations

  • Published online on: December 13, 2017     https://doi.org/10.3892/ol.2017.7612
  • Pages:2574-2582
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Abstract

The present study developed a novel laboratory-based algorithm to predict long‑term survival rates in patients undergoing curative resection for solitary hepatitis B virus (HBV)‑related hepatocellular carcinoma (HCC). The present study included 426 patients with solitary HBV‑related HCC who underwent surgery for primary tumors at a single center between 2003 and 2012. Demographic characteristics, laboratory analysis, clinical pathology and immunohistochemistry of topoisomerase II‑a and Ki67 were analyzed. A simple prognostic risk calculator was developed using regression coefficients from multivariate models. A prognostic risk calculator incorporating tumor encapsulation, neutrophil-to-lymphocyte ratio, vascular invasion, α‑fetoprotein level, Edmondson‑Steiner classification, Topo II‑α, prognostic nutritional index and Child‑Pugh grade was constructed. The prognostic model demonstrated good discrimination with a C‑index prior to adjustment of 0.81 (95% confidence interval: 0.78‑0.84) and a bootstrap‑corrected C‑index of 0.81. Kaplan‑Meier curves demonstrated that the probabilities of overall survival rates in the low‑risk group were increased compared with those in the high‑risk group. The areas under the receiver operating characteristic curve using the method were greater compared with those under the 7th Tumor‑Node‑Metastasis system and Cancer of the Liver Italian Program scoring system [0.83 vs. 0.62 and 0.77 (P<0.001), respectively]. The simple prognostic model of the present study accurately predicted survival rates in patients. Such a prognostic risk calculator for staging patients undergoing curative resection for solitary HBV‑related HCC facilitates clinical surveillance and therapy.

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February 2018
Volume 15 Issue 2

Print ISSN: 1792-1074
Online ISSN:1792-1082

2016 Impact Factor: 1.39
Ranked #68/217 Oncology
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APA
Cao, Y., Jiang, Z., Wang, S., Zhang, H., Jiang, Y., & Lv, L. (2018). Prediction of long‑term survival rates in patients undergoing curative resection for solitary hepatocellular carcinoma. Oncology Letters, 15, 2574-2582. https://doi.org/10.3892/ol.2017.7612
MLA
Cao, Y., Jiang, Z., Wang, S., Zhang, H., Jiang, Y., Lv, L."Prediction of long‑term survival rates in patients undergoing curative resection for solitary hepatocellular carcinoma". Oncology Letters 15.2 (2018): 2574-2582.
Chicago
Cao, Y., Jiang, Z., Wang, S., Zhang, H., Jiang, Y., Lv, L."Prediction of long‑term survival rates in patients undergoing curative resection for solitary hepatocellular carcinoma". Oncology Letters 15, no. 2 (2018): 2574-2582. https://doi.org/10.3892/ol.2017.7612