Open Access

Long non-coding RNA cartilage injury-related promotes malignancy in bladder cancer

  • Authors:
    • Xuebao Xiang
    • Jiefu Huang
    • Wenfa Mo
    • Leiming Jiang
    • Wenguo Sun
    • Pengcheng Li
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  • Published online on: December 21, 2017     https://doi.org/10.3892/ol.2017.7678
  • Pages: 3049-3055
  • Copyright: © Xiang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Recent advances have highlighted the important roles of long non‑coding RNAs (lncRNAs) in a number of biological processes, including oncogenesis. However, the function of lncRNA cartilage injury‑related (lncRNA‑CIR) in bladder cancer progression remains elusive. A novel function for lncRNA‑CIR in bladder cancer was identified in the present study. Reverse transcription quantitative polymerase chain reaction, viability, invasion assay and in vivo implantation were used to evaluate the role of lncRNA‑CIR. It was identified that the expression of lncRNA‑CIR was frequently upregulated in 52 cancerous tissues and selected bladder cancer cell lines. Additionally, upregulating lncRNA‑CIR was demonstrated to promote viability and invasion in T24 and SW780 cells, whereas siRNA‑mediated lncRNA‑CIR‑knockdown consistently exhibited the opposite effects. High lncRNA‑CIR levels also dictated poor overall survival among patients with bladder cancer. Furthermore, in vivo implantation experiments also supported a tumorigenic function for lncRNA‑CIR, as decreasing lncRNA‑CIR levels markedly attenuated Ki‑67 staining and xenograft tumor growth. Overall, the present study identified a novel function of lncRNA‑CIR and indicates that lncRNA‑CIR may serve as a potential biomarker for bladder cancer treatment.
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March-2018
Volume 15 Issue 3

Print ISSN: 1792-1074
Online ISSN:1792-1082

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Spandidos Publications style
Xiang X, Huang J, Mo W, Jiang L, Sun W and Li P: Long non-coding RNA cartilage injury-related promotes malignancy in bladder cancer. Oncol Lett 15: 3049-3055, 2018
APA
Xiang, X., Huang, J., Mo, W., Jiang, L., Sun, W., & Li, P. (2018). Long non-coding RNA cartilage injury-related promotes malignancy in bladder cancer. Oncology Letters, 15, 3049-3055. https://doi.org/10.3892/ol.2017.7678
MLA
Xiang, X., Huang, J., Mo, W., Jiang, L., Sun, W., Li, P."Long non-coding RNA cartilage injury-related promotes malignancy in bladder cancer". Oncology Letters 15.3 (2018): 3049-3055.
Chicago
Xiang, X., Huang, J., Mo, W., Jiang, L., Sun, W., Li, P."Long non-coding RNA cartilage injury-related promotes malignancy in bladder cancer". Oncology Letters 15, no. 3 (2018): 3049-3055. https://doi.org/10.3892/ol.2017.7678