Ursolic acid activates the apoptosis of prostate cancer via ROCK/PTEN mediated mitochondrial translocation of cofilin-1

  • Authors:
    • Dawei Mu
    • Gaobiao Zhou
    • Jianye Li
    • Bin Su
    • Heqing Guo
  • View Affiliations

  • Published online on: December 27, 2017     https://doi.org/10.3892/ol.2017.7689
  • Pages: 3202-3206
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Abstract

Ursolic acid has various pharmacological activities, and can reduce blood fat as well as having antihepatic, antitumoral, anti‑inflammatory and antiviral properties. However, the pro‑apoptotic mechanism by which ursolic acid influences human prostate cancer requires additional study. The aim of the present study was to assess whether ursolic acid activates the apoptosis of prostate cancer and to investigate the mechanism by which the Rho‑associated protein kinase 1 (ROCK1)/phosphatase and tensin homolog (PTEN) signaling pathway performs a role in ursolic acid‑mediated cofilin‑1 to induce apoptosis in human prostate cancer. Firstly, the present study determined the pro‑apoptotic mechanism by which ursolic acid influences the cell proliferation and apoptosis of human prostate LNCaP cancer cells. Caspase‑3/9 activities and ROCK1, PTEN, Cofilin‑1 and cytochrome c protein expression levels were also analyzed. In the present study, it is reported that the pro‑apoptotic mechanism of ursolic acid potently suppressed the cell proliferation of human prostate LNCaP cancer cells. The present study revealed that the mediation of ROCK1/PTEN‑cofilin‑1/cytochrome c protein expression activates caspase‑3/9 activities which subsequently induced the apoptosis of human prostate cancer cells. In conclusion, these findings demonstrated that ursolic acid activates the apoptosis of prostate cancer via ROCK/PTEN mediated cofilin‑1/cytochrome c which mediated caspase‑3/9 activities.
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March-2018
Volume 15 Issue 3

Print ISSN: 1792-1074
Online ISSN:1792-1082

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Spandidos Publications style
Mu D, Zhou G, Li J, Su B and Guo H: Ursolic acid activates the apoptosis of prostate cancer via ROCK/PTEN mediated mitochondrial translocation of cofilin-1. Oncol Lett 15: 3202-3206, 2018.
APA
Mu, D., Zhou, G., Li, J., Su, B., & Guo, H. (2018). Ursolic acid activates the apoptosis of prostate cancer via ROCK/PTEN mediated mitochondrial translocation of cofilin-1. Oncology Letters, 15, 3202-3206. https://doi.org/10.3892/ol.2017.7689
MLA
Mu, D., Zhou, G., Li, J., Su, B., Guo, H."Ursolic acid activates the apoptosis of prostate cancer via ROCK/PTEN mediated mitochondrial translocation of cofilin-1". Oncology Letters 15.3 (2018): 3202-3206.
Chicago
Mu, D., Zhou, G., Li, J., Su, B., Guo, H."Ursolic acid activates the apoptosis of prostate cancer via ROCK/PTEN mediated mitochondrial translocation of cofilin-1". Oncology Letters 15, no. 3 (2018): 3202-3206. https://doi.org/10.3892/ol.2017.7689