Discoidin domain receptor 1: New star in cancer-targeted therapy and its complex role in breast carcinoma (Review)

  • Authors:
    • Hui Jing
    • Jingyuan Song
    • Junnian Zheng
  • View Affiliations

  • Published online on: January 15, 2018     https://doi.org/10.3892/ol.2018.7795
  • Pages: 3403-3408
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Abstract

Discoidin domain receptor 1 (DDR1) is a receptor tyrosine kinase activated by various types of collagens that performs a critical role in cell attachment, migration, survival and proliferation. The functions of DDR1 in various types of tumor have been studied extensively. However, in breast carcinoma, the roles of collagen‑evoked DDR1 remain ill defined. Although a number of studies have reported that DDR1 promotes apoptosis and inhibits migration in breast carcinoma, it has also been reported to be associated with tumor cell survival, chemoresistance to genotoxic drugs and the facilitation of invasion. The present review summarizes current progress and the complex effects of DDR1 in the field of breast carcinoma, and presents DDR1 as a promising therapeutic target.
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March-2018
Volume 15 Issue 3

Print ISSN: 1792-1074
Online ISSN:1792-1082

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Copy and paste a formatted citation
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Spandidos Publications style
Jing H, Song J and Zheng J: Discoidin domain receptor 1: New star in cancer-targeted therapy and its complex role in breast carcinoma (Review). Oncol Lett 15: 3403-3408, 2018
APA
Jing, H., Song, J., & Zheng, J. (2018). Discoidin domain receptor 1: New star in cancer-targeted therapy and its complex role in breast carcinoma (Review). Oncology Letters, 15, 3403-3408. https://doi.org/10.3892/ol.2018.7795
MLA
Jing, H., Song, J., Zheng, J."Discoidin domain receptor 1: New star in cancer-targeted therapy and its complex role in breast carcinoma (Review)". Oncology Letters 15.3 (2018): 3403-3408.
Chicago
Jing, H., Song, J., Zheng, J."Discoidin domain receptor 1: New star in cancer-targeted therapy and its complex role in breast carcinoma (Review)". Oncology Letters 15, no. 3 (2018): 3403-3408. https://doi.org/10.3892/ol.2018.7795