Characteristics of breast metastases from non-breast solid tumors in 22 patients from a southern Chinese population

Sun,Peng; Chen,Jiewei; Lu,Jiabin; Luo,Rongzhen; Li,Mei; He,Jiehua

doi:10.3892/ol.2018.7741

Characteristics of breast metastases from non-breast solid tumors in 22 patients from a southern Chinese population

Authors:
- Peng Sun
- Jiewei Chen
- Jiabin Lu
- Rongzhen Luo
- Mei Li
- Jiehua He
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Affiliations: State Key Laboratory of Oncology in South China, Department of Pathology, Sun Yat‑sen University Cancer Center, Collaborative Innovation Center for Cancer Medicine, Guangzhou, Guangdong 510080, P.R. China
Published online on: January 8, 2018 https://doi.org/10.3892/ol.2018.7741
Pages: 3685-3693
Copyright: © Sun et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Breast metastases from solid non-breast tumor types are rare; however, they should be always considered in the differential diagnosis of a breast lesion owing to the associated poor patient prognosis and the requirement of different therapeutic strategies compared with those used to treat primary breast cancer. The aim of the current study was to summarize the characteristics of metastases to the breast in a southern Chinese population. The medical records and pathological sections of 22 patients with pathologically confirmed extra‑mammary metastases to the breast that presented to Sun Yat‑sen University Cancer Center between January 2000 and December 2015 were retrospectively reviewed. The median age of onset for breast metastasis was 43 years (range, 10‑62 years) and 19 (86.4%) patients had a known history of a primary tumor. The mean interval from diagnosis of the primary tumor to breast metastasis was 16.5 months (range, 6‑56 months). A unilateral (45.5% left, 36.4% right), upper outer quadrant (15/22, 68.2%) lesion of the breast was most frequently initially detected by self‑checking (63.6%). The most common origin of the primary tumor was the lung (22.7%). Nasopharyngeal carcinoma accounted for a high proportion of the metastases (18.2%). The median duration of survival from the time of diagnosis of a breast metastasis was 14 months (range, 2‑74 months). A total of 10 patients (45.5%) succumbed to the disease. The results also indicated that overall survival in patients that underwent surgery was improved compared with patients who did not undergo surgery. The results of the present study demonstrated that clinical history, imaging findings, pathology from the primary tumor and immunostaining were required in combination to establish an accurate diagnosis. Further investigation into the improvement of the prognosis of patients with metastases to the breast following surgery is required.

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1	Alva S and Shetty-Alva N: An update of tumor metastasis to the breast data. Arch Surg. 134:4501999. View Article : Google Scholar : PubMed/NCBI
2	Akçay MN: Metastatic disease in the breast. Breast. 11:526–528. 2002. View Article : Google Scholar : PubMed/NCBI
3	Williams SA, Ehlers RA II, Hunt KK, Yi M, Kuerer HM, Singletary SE, Ross MI, Feig BW, Symmans WF and Meric-Bernstam F: Metastases to the breast from nonbreast solid neoplasms: Presentation and determinants of survival. Cancer. 110:731–737. 2007. View Article : Google Scholar : PubMed/NCBI
4	Lee SK, Kim WW, Kim SH, Hur SM, Kim S, Choi JH, Cho EY, Han SY, Hahn BK, Choe JH, et al: Characteristics of metastasis in the breast from extramammary malignancies. J Surg Oncol. 101:137–140. 2010. View Article : Google Scholar : PubMed/NCBI
5	Sippo DA, Kulkarni K, Carlo PD, Lee B, Eisner D, Cimino-Mathews A and Harvey SC: Metastatic disease to the breast from extramammary malignancies: A multimodality pictorial review. Curr Probl Diagn Radiol. 45:225–232. 2016. View Article : Google Scholar : PubMed/NCBI
6	Manini C, Pietribiasi F, Sapino A and Donadio S: Serous cystadenocarcinoma of the ovary with simultaneous breast metastases. Description of a case. Pathologica. 90:152–155. 1998.(In Italian).
7	Hanna NN, O'Donnell K and Wolfe GR: Alveolar soft part sarcoma metastatic to the breast. J Surg Oncol. 61:159–162. 1996. View Article : Google Scholar : PubMed/NCBI
8	Oksüzoğlu B, Abali H, Güler N, Baltali E and Ozişik Y: Metastasis to the breast from nonmammarian solid neoplasms: A report of five cases. Med Oncol. 20:295–300. 2003. View Article : Google Scholar : PubMed/NCBI
9	Liberman L and Menell JH: Breast imaging reporting and data system (BI-RADS). Radiol Clin North Am. 40:409–430, v. 2002. View Article : Google Scholar : PubMed/NCBI
10	Hajdu SI and Urban JA: Cancers metastatic to the breast. Cancer. 29:1691–1696. 1972. View Article : Google Scholar : PubMed/NCBI
11	Hamby LS, McGrath PC, Cibull ML and Schwartz RW: Gastric carcinoma metastatic to the breast. J Surg Oncol. 48:117–121. 1991. View Article : Google Scholar : PubMed/NCBI
12	Toombs BD and Kalisher L: Metastatic disease to the breast: Clinical, pathologic, and radiographic features. AJR Am J Roentgenol. 129:673–676. 1977. View Article : Google Scholar : PubMed/NCBI
13	Mihai R, Christie-Brown J and Bristol J: Breast metastases from colorectal carcinoma. Breast. 13:155–158. 2004. View Article : Google Scholar : PubMed/NCBI
14	Brouckaert O, Rudolph A, Laenen A, Keeman R, Bolla MK, Wang Q, Soubry A, Wildiers H, Andrulis IL, Arndt V, et al: Reproductive profiles and risk of breast cancer subtypes: A multi-center case-only study. Breast Cancer Res. 19:1192017. View Article : Google Scholar : PubMed/NCBI
15	Vergier B, Trojani M, de Mascarel I, Coindre JM and Le Treut A: Metastases to the breast: Differential diagnosis from primary breast carcinoma. J Surg Oncol. 48:112–116. 1991. View Article : Google Scholar : PubMed/NCBI
16	Nayar M, Chandra M, Aggarwal R and Chander S: Carcinoma cervix presenting as primary breast malignancy. Indian J Pathol Microbiol. 30:283–286. 1987.PubMed/NCBI
17	DeLair DF, Corben AD, Catalano JP, Vallejo CE, Brogi E and Tan LK: Non-mammary metastases to the breast and axilla: A study of 85 cases. Mod Pathol. 26:343–349. 2013. View Article : Google Scholar : PubMed/NCBI
18	Yeh CN, Lin CH and Chen MF: Clinical and ultrasonographic characteristics of breast metastases from extramammary malignancies. Am Surg. 70:287–290. 2004.PubMed/NCBI
19	Mun SH, Ko EY, Han BK, Shin JH, Kim SJ and Cho EY: Breast metastases from extramammary malignancies: Typical and atypical ultrasound features. Korean J Radiol. 15:20–28. 2014. View Article : Google Scholar : PubMed/NCBI
20	Bohman LG, Bassett LW, Gold RH and Voet R: Breast metastases from extramammary malignancies. Radiology. 144:309–312. 1982. View Article : Google Scholar : PubMed/NCBI
21	McCrea ES, Johnston C and Haney PJ: Metastases to the breast. AJR Am J Roentgenol. 141:685–690. 1983. View Article : Google Scholar : PubMed/NCBI
22	Lee SH, Park JM, Kook SH, Han BK and Moon WK: Metastatic tumors to the breast: Mammographic and ultrasonographic findings. J Ultrasound Med. 19:257–262. 2000. View Article : Google Scholar : PubMed/NCBI
23	Vizcaíno I, Torregrosa A, Higueras V, Morote V, Cremades A, Torres V, Olmos S and Molins C: Metastasis to the breast from extramammary malignancies: A report of four cases and a review of literature. Eur Radiol. 11:1659–1665. 2001. View Article : Google Scholar : PubMed/NCBI
24	Surov A, Fiedler E, Holzhausen HJ, Ruschke K, Schmoll HJ and Spielmann RP: Metastases to the breast from non-mammary malignancies: Primary tumors, prevalence, clinical signs, and radiological features. Acad Radiol. 18:565–574. 2011. View Article : Google Scholar : PubMed/NCBI
25	Torjesen I: Adding ultrasound to mammography could increase breast cancer detection in Asian women. BMJ. 351:h59262015. View Article : Google Scholar : PubMed/NCBI
26	Phadke S, Thomas A, Yang L, Moore C, Xia C and Schroeder MC: Frequency and clinical significance of extramammary findings on breast magnetic resonance imaging. Clin Breast Cancer. 16:424–429. 2016. View Article : Google Scholar : PubMed/NCBI
27	Benveniste AP, Marom EM, Benveniste MF, Mawlawi OR, Miranda RN and Yang W: Metastases to the breast from extramammary malignancies-PET/CT findings. Eur J Radiol. 83:1106–1112. 2014. View Article : Google Scholar : PubMed/NCBI
28	Buisman FE, van Gelder L, Menke-Pluijmers MB, Bisschops BH, Plaisier PW and Westenend PJ: Non-primary breast malignancies: A single institution's experience of a diagnostic challenge with important therapeutic consequences-a retrospective study. World J Surg Oncol. 14:1662016. View Article : Google Scholar : PubMed/NCBI
29	Leach BI, Sun B, Petrovic L and Liu SV: Breast metastasis from nasopharyngeal carcinoma: A case report and review of the literature. Oncol Lett. 5:1859–1861. 2013. View Article : Google Scholar : PubMed/NCBI
30	Li S and Yang J: Nasopharyngeal carcinoma metastasis to the mammary gland: A case report. Oncol Lett. 9:275–277. 2015. View Article : Google Scholar : PubMed/NCBI
31	Georgiannos SN, Chin J, Goode AW and Sheaff M: Secondary neoplasms of the breast: A survey of the 20th century. Cancer. 92:2259–2266. 2001. View Article : Google Scholar : PubMed/NCBI
32	Tornos C, Soslow R, Chen S, Akram M, Hummer AJ, Abu-Rustum N, Norton L and Tan LK: Expression of WT1, CA 125, and GCDFP-15 as useful markers in the differential diagnosis of primary ovarian carcinomas versus metastatic breast cancer to the ovary. Am J Surg Pathol. 29:1482–1489. 2005. View Article : Google Scholar : PubMed/NCBI
33	Dennis JL, Hvidsten TR, Wit EC, Komorowski J, Bell AK, Downie I, Mooney J, Verbeke C, Bellamy C, Keith WN and Oien KA: Markers of adenocarcinoma characteristic of the site of origin: Development of a diagnostic algorithm. Clin Cancer Res. 11:3766–3772. 2005. View Article : Google Scholar : PubMed/NCBI
34	Moritani S, Ichihara S, Hasegawa M, Endo T, Oiwa M, Yoshikawa K, Sato Y, Aoyama H, Hayashi T and Kushima R: Serous papillary adenocarcinoma of the female genital organs and invasive micropapillary carcinoma of the breast. Are WT1, CA125, and GCDFP-15 useful in differential diagnosis? Hum Pathol. 39:666–671. 2008.
35	Lagendijk JH, Mullink H, van Diest PJ, Meijer GA and Meijer CJ: Immunohistochemical differentiation between primary adenocarcinomas of the ovary and ovarian metastases of colonic and breast origin. Comparison between a statistical and an intuitive approach. J Clin Pathol. 52:283–290. 1999. View Article : Google Scholar : PubMed/NCBI
36	Recine MA, Deavers MT, Middleton LP, Silva EG and Malpica A: Serous carcinoma of the ovary and peritoneum with metastases to the breast and axillary lymph nodes: A potential pitfall. Am J Surg Pathol. 28:1646–1651. 2004. View Article : Google Scholar : PubMed/NCBI
37	Lee BH, Hecht JL, Pinkus JL and Pinkus GS: WT1, estrogen receptor, and progesterone receptor as markers for breast or ovarian primary sites in metastatic adenocarcinoma to body fluids. Am J Clin Pathol. 117:745–750. 2002. View Article : Google Scholar : PubMed/NCBI
38	Espinosa I, Gallardo A, D'Angelo E, Mozos A, Lerma E and Prat J: Simultaneous carcinomas of the breast and ovary: Utility of Pax-8, WT-1, and GATA3 for distinguishing independent primary tumors from metastases. Int J Gynecol Pathol. 34:257–265. 2015. View Article : Google Scholar : PubMed/NCBI
39	Tempfer CB, El Fizazi N, Ergonenc H and Solass W: Metastasis of ovarian cancer to the breast: A report of two cases and a review of the literature. Oncol Lett. 11:4008–4012. 2016. View Article : Google Scholar : PubMed/NCBI
40	Rossfeld KK and Carson WE III: Surgical management of ovarian carcinoma metastatic to the breast and axilla: A role for metastasectomy? J Surg Oncol. 112:581–584. 2015. View Article : Google Scholar : PubMed/NCBI