1
|
Leong SS, Wee J, Tay MH, Toh CK, Tan SB,
Thng CH, Foo KF, Lim WT, Tan T and Tan EH: Paclitaxel, carboplatin,
and gemcitabine in metastatic nasopharyngeal carcinoma: A Phase II
trial using a triplet combination. Cancer. 103:569–575. 2005.
View Article : Google Scholar : PubMed/NCBI
|
2
|
Leong SS, Wee J, Rajan S, Toh CK, Lim WT,
Hee SW, Tay MH, Poon D and Tan EH: Triplet combination of
gemcitabine, paclitaxel, and carboplatin followed by maintenance
5-fluorouracil and folinic acid in patients with metastatic
nasopharyngeal carcinoma. Cancer. 113:1332–1337. 2008. View Article : Google Scholar : PubMed/NCBI
|
3
|
Vaupel P, Kallinowski F and Okunieff P:
Blood flow, oxygen and nutrient supply, and metabolic
microenvironment of human tumors: A review. Cancer Res.
49:6449–6465. 1989.PubMed/NCBI
|
4
|
Gatenby RA and Gillies RJ: A
microenvironmental model of carcinogenesis. Nat Rev Cancer.
8:56–61. 2008. View
Article : Google Scholar : PubMed/NCBI
|
5
|
Fang JS, Gillies RD and Gatenby RA:
Adaptation to hypoxia and acidosis in carcinogenesis and tumor
progression. Semin Cancer Biol. 18:330–337. 2008. View Article : Google Scholar : PubMed/NCBI
|
6
|
Hashim AI, Zhang X, Wojtkowiak JW,
Martinez GV and Gillies RJ: Imaging pH and metastasis. NMR Biomed.
24:582–591. 2011.PubMed/NCBI
|
7
|
Peppicelli S, Bianchini F and Calorini L:
Extracellular acidity, a ‘reappreciated’ trait of tumor environment
driving malignancy: Perspectives in diagnosis and therapy. Cancer
Metastasis Rev. 33:823–832. 2014. View Article : Google Scholar : PubMed/NCBI
|
8
|
Raghunand N and Gillies RJ: pH and drug
resistance in tumors. Drug Resist Updat. 3:39–47. 2000. View Article : Google Scholar : PubMed/NCBI
|
9
|
Wojtkowiak JW, Verduzco D, Schramm KJ and
Gillies RJ: Drug resistance and cellular adaptation to tumor acidic
pH microenvironment. Mol Pharm. 8:2032–2038. 2011. View Article : Google Scholar : PubMed/NCBI
|
10
|
Trédan O, Galmarini CM, Patel K and
Tannock IF: Drug resistance and the solid tumor microenvironment. J
Natl Cancer Inst. 99:1441–1454. 2007. View Article : Google Scholar : PubMed/NCBI
|
11
|
Parks SK, Chiche J and Pouysségur J:
Disrupting proton dynamics and energy metabolism for cancer
therapy. Nat Rev Cancer. 13:611–623. 2013. View Article : Google Scholar : PubMed/NCBI
|
12
|
Mahoney BP, Raghunand N, Baggett B and
Gillies RJ: Tumor acidity, ion trapping and chemotherapeutics. I.
Acid pH affects the distribution of chemotherapeutic agents in
vitro. Biochem Pharmacol. 66:1207–1218. 2003. View Article : Google Scholar : PubMed/NCBI
|
13
|
Raghunand N, Mahoney BP and Gillies RJ:
Tumor acidity, ion trapping and chemotherapeutics. II. pH-dependent
partition coefficients predict importance of ion trapping on
pharmacokinetics of weakly basic chemotherapeutic agents. Biochem
Pharmacol. 66:1219–1229. 2003. View Article : Google Scholar : PubMed/NCBI
|
14
|
Thiery JP: Epithelial-mesenchymal
transitions in development and pathologies. Curr Opin Cell Biol.
15:740–746. 2003. View Article : Google Scholar : PubMed/NCBI
|
15
|
Thiery JP, Acloque H, Huang RY and Nieto
MA: Epithelial-mesenchymal transitions in development and disease.
Cell. 139:871–890. 2009. View Article : Google Scholar : PubMed/NCBI
|
16
|
Wang Z, Li Y, Ahmad A, Azmi AS, Kong D,
Banerjee S and Sarkar FH: Targeting miRNAs involved in cancer stem
cell and EMT regulation: An emerging concept in overcoming drug
resistance. Drug Resist Updat. 13:109–118. 2010. View Article : Google Scholar : PubMed/NCBI
|
17
|
Kajiyama H, Shibata K, Terauchi M,
Yamashita M, Ino K, Nawa A and Kikkawa F: Chemoresistance to
paclitaxel induces epithelial-mesenchymal transition and enhances
metastatic potential for epithelial ovarian carcinoma cells. Int J
Oncol. 31:277–283. 2007.PubMed/NCBI
|
18
|
Lee SG, Kang DC, DeSalle R, Sarkar D and
Fisher PB: AEG-1/MTDH/LYRIC, the beginning: Initial cloning,
structure, expression profile, and regulation of expression. Adv
Cancer Res. 120:1–38. 2013. View Article : Google Scholar : PubMed/NCBI
|
19
|
Emdad L, Das SK, Dasgupta S, Hu B, Sarkar
D and Fisher PB: AEG-1/MTDH/LYRIC: Signaling pathways, downstream
genes, interacting proteins, and regulation of tumor angiogenesis.
Adv Cancer Res. 120:75–111. 2013. View Article : Google Scholar : PubMed/NCBI
|
20
|
Hu G, Chong RA, Yang Q, Wei Y, Blanco MA,
Li F, Reiss M, Au JL, Haffty BG and Kang Y: MTDH activation by 8q22
genomic gain promotes chemoresistance and metastasis of
poor-prognosis breast cancer. Cancer Cell. 15:9–20. 2009.
View Article : Google Scholar : PubMed/NCBI
|
21
|
Yoo BK, Gredler R, Vozhilla N, Su ZZ, Chen
D, Forcier T, Shah K, Saxena U, Hansen U, Fisher PB and Sarkar D:
Identification of genes conferring resistance to 5-fluorouracil.
Proc Natl Acad Sci USA. 106:pp. 12938–12943. 2009; View Article : Google Scholar : PubMed/NCBI
|
22
|
Yoo BK, Chen D, Su ZZ, Gredler R, Yoo J,
Shah K, Fisher PB and Sarkar D: Molecular mechanism of
chemoresistance by astrocyte elevated gene-1. Cancer Res.
70:3249–3258. 2010. View Article : Google Scholar : PubMed/NCBI
|
23
|
Meng X, Thiel KW and Leslie KK: Drug
resistance mediated by AEG-1/MTDH/LYRIC. Adv Cancer Res.
120:135–157. 2013. View Article : Google Scholar : PubMed/NCBI
|
24
|
Zhang J, Zhang Y, Liu S, Zhang Q, Wang Y,
Tong L, Chen X, Ji Y, Shang Q, Xu B, et al: Metadherin confers
chemoresistance of cervical cancer cells by inducing autophagy and
activating ERK/NF-κB pathway. Tumour Biol. 34:2433–2440. 2013.
View Article : Google Scholar : PubMed/NCBI
|
25
|
Liu X, Wang D, Liu H, Feng Y, Zhu T, Zhang
L, Zhu B and Zhang Y: Knockdown of astrocyte elevated gene-1
(AEG-1) in cervical cancer cells decreases their invasiveness,
epithelial to mesenchymal transition, and chemoresistance. Cell
Cycle. 13:1702–1707. 2014. View
Article : Google Scholar : PubMed/NCBI
|
26
|
Ward A, Balwierz A, Zhang JD, Küblbeck M,
Pawitan Y, Hielscher T, Wiemann S and Sahin Ö: Re-expression of
microRNA-375 reverses both tamoxifen resistance and accompanying
EMT-like properties in breast cancer. Oncogene. 32:1173–1182. 2013.
View Article : Google Scholar : PubMed/NCBI
|
27
|
Zheng J, Li C, Wu X, Liu M, Sun X, Yang Y,
Hao M, Sheng S, Sun Y, Zhang H, et al: Huaier polysaccharides
suppresses hepatocarcinoma MHCC97-H cell metastasis via
inactivation of EMT and AEG-1 pathway. Int J Biol Macromol.
64:106–110. 2014. View Article : Google Scholar : PubMed/NCBI
|
28
|
Schmittgen TD and Livak KJ: Analyzing
real-time PCR data by the comparative C(T) method. Nat Protoc.
3:1101–1108. 2008. View Article : Google Scholar : PubMed/NCBI
|
29
|
Yu C, Liu Y, Huang D, Dai Y, Cai G, Sun J,
Xu T, Tian Y and Zhang X: TGF-β1 mediates epithelial to mesenchymal
transition via the TGF-β/Smad pathway in squamous cell carcinoma of
the head and neck. Oncol Rep. 25:1581–1587. 2011.PubMed/NCBI
|
30
|
Yu C, Liu Y, Tan H, Li G, Su Z, Ren S, Zhu
G, Tian Y, Qiu Y and Zhang X: Metadherin regulates metastasis of
squamous cell carcinoma of the head and neck via AKT signalling
pathway-mediated epithelial-mesenchymal transition. Cancer Lett.
343:258–267. 2014. View Article : Google Scholar : PubMed/NCBI
|
31
|
Zhang C, Li HZ, Qian BJ, Liu CM, Guo F and
Lin MC: MTDH/AEG-1-based DNA vaccine suppresses metastasis and
enhances chemosensitivity to paclitaxel in pelvic lymph node
metastasis. Biomed Pharmacother. 70:217–226. 2015. View Article : Google Scholar : PubMed/NCBI
|
32
|
Chua MLK, Wee JTS, Hui EP and Chan ATC:
Nasopharyngeal carcinoma. Lancet. 387:1012–1024. 2016. View Article : Google Scholar : PubMed/NCBI
|
33
|
Rotin D, Robinson B and Tannock IF:
Influence of hypoxia and an acidic environment on the metabolism
and viability of cultured cells: Potential implications for cell
death in tumors. Cancer Res. 46:2821–2826. 1986.PubMed/NCBI
|
34
|
Tannock IF and Rotin D: Acid pH in tumors
and its potential for therapeutic exploitation. Cancer Res.
49:4373–4384. 1989.PubMed/NCBI
|
35
|
Yamagata M and Tannock IF: The chronic
administration of drugs that inhibit the regulation of
intracellular pH: In vitro and anti-tumour effects. Br J Cancer.
73:1328–1334. 1996. View Article : Google Scholar : PubMed/NCBI
|
36
|
Vukovic V and Tannock IF: Influence of low
pH on cytotoxicity of paclitaxel, mitoxantrone and topotecan. Br J
Cancer. 75:1167–1172. 1997. View Article : Google Scholar : PubMed/NCBI
|
37
|
Huizing MT, Misser VH, Pieters RC, ten
Bokkel Huinink WW, Veenhof CH, Vermorken JB, Pinedo HM and Beijnen
JH: Taxanes: A new class of antitumor agents. Cancer Invest.
13:381–404. 1995. View Article : Google Scholar : PubMed/NCBI
|
38
|
Gomes LR, Terra LF, Sogayar MC and
Labriola L: Epithelial-mesenchymal transition: Implications in
cancer progression and metastasis. Curr Pharm Biotechnol.
12:1881–1890. 2011. View Article : Google Scholar : PubMed/NCBI
|
39
|
Savagner P: The epithelial-mesenchymal
transition (EMT) phenomenon. Ann Oncol. 21 Suppl 7:vii89–vii92.
2010. View Article : Google Scholar : PubMed/NCBI
|
40
|
Lim J and Thiery JP:
Epithelial-mesenchymal transitions: Insights from development.
Development. 139:3471–3486. 2012. View Article : Google Scholar : PubMed/NCBI
|
41
|
Peppicelli S, Bianchini F, Torre E and
Calorini L: Contribution of acidic melanoma cells undergoing
epithelial-to-mesenchymal transition to aggressiveness of
non-acidic melanoma cells. Clin Exp Metastasis. 31:423–433. 2014.
View Article : Google Scholar : PubMed/NCBI
|
42
|
Suzuki A, Maeda T, Baba Y, Shimamura K and
Kato Y: Acidic extracellular pH promotes epithelial mesenchymal
transition in Lewis lung carcinoma model. Cancer Cell Int.
14:1292014. View Article : Google Scholar : PubMed/NCBI
|
43
|
De Craene B and Berx G: Regulatory
networks defining EMT during cancer initiation and progression. Nat
Rev Cancer. 13:97–110. 2013. View Article : Google Scholar : PubMed/NCBI
|
44
|
Yang AD, Fan F, Camp ER, van Buren G, Liu
W, Somcio R, Gray MJ, Cheng H, Hoff PM and Ellis LM: Chronic
oxaliplatin resistance induces epithelial-to-mesenchymal transition
in colorectal cancer cell lines. Clin Cancer Res. 12:4147–4153.
2006. View Article : Google Scholar : PubMed/NCBI
|
45
|
Shah AN, Summy JM, Zhang J, Park SI,
Parikh NU and Gallick GE: Development and characterization of
gemcitabine-resistant pancreatic tumor cells. Ann Surg Oncol.
14:3629–3637. 2007. View Article : Google Scholar : PubMed/NCBI
|
46
|
Zhang P, Liu H, Xia F, Zhang QW, Zhang YY,
Zhao Q, Chao ZH, Jiang ZW and Jiang CC: Epithelial-mesenchymal
transition is necessary for acquired resistance to cisplatin and
increases the metastatic potential of nasopharyngeal carcinoma
cells. Int J Mol Med. 33:151–159. 2014. View Article : Google Scholar : PubMed/NCBI
|
47
|
Zhou Z, Zhang L, Xie B, Wang X, Yang X,
Ding N, Zhang J, Liu Q, Tan G, Feng D and Sun LQ: FOXC2 promotes
chemoresistance in nasopharyngeal carcinomas via induction of
epithelial mesenchymal transition. Cancer Lett. 363:137–145. 2015.
View Article : Google Scholar : PubMed/NCBI
|
48
|
Fukumura D, Xu L, Chen Y, Gohongi T, Seed
B and Jain RK: Hypoxia and acidosis independently up-regulate
vascular endothelial growth factor transcription in brain tumors in
vivo. Cancer Res. 61:6020–6024. 2001.PubMed/NCBI
|
49
|
Shi Q, Abbruzzese JL, Huang S, Fidler IJ,
Xiong Q and Xie K: Constitutive and inducible interleukin 8
expression by hypoxia and acidosis renders human pancreatic cancer
cells more tumorigenic and metastatic. Clin Cancer Res.
5:3711–3721. 1999.PubMed/NCBI
|
50
|
Shi Q, Xiong Q, Le X and Xie K: Regulation
of interleukin-8 expression by tumor-associated stress factors. J
Interferon Cytokine Res. 21:553–566. 2001. View Article : Google Scholar : PubMed/NCBI
|
51
|
Kato Y, Ozawa S, Tsukuda M, Kubota E,
Miyazaki K, St-Pierre Y and Hata R: Acidic extracellular pH
increases calcium influx-triggered phospholipase D activity along
with acidic sphingomyelinase activation to induce matrix
metalloproteinase-9 expression in mouse metastatic melanoma. FEBS
J. 274:3171–3183. 2007. View Article : Google Scholar : PubMed/NCBI
|
52
|
Hu G, Wei Y and Kang Y: The multifaceted
role of MTDH/AEG-1 in cancer progression. Clin Cancer Res.
15:5615–5620. 2009. View Article : Google Scholar : PubMed/NCBI
|
53
|
Yoo BK, Emdad L, Lee SG, Su ZZ,
Santhekadur P, Chen D, Gredler R, Fisher PB and Sarkar D: Astrocyte
elevated gene-1 (AEG-1): A multifunctional regulator of normal and
abnormal physiology. Pharmacol Ther. 130:1–8. 2011. View Article : Google Scholar : PubMed/NCBI
|
54
|
Liu Y, Su Z, Li G, Yu C, Ren S, Huang D,
Fan S, Tian Y, Zhang X and Qiu Y: Increased expression of
metadherin protein predicts worse disease-free and overall survival
in laryngeal squamous cell carcinoma. Int J Cancer. 133:671–679.
2013. View Article : Google Scholar : PubMed/NCBI
|
55
|
Zhu GC, Yu CY, She L, Tan HL, Li G, Ren
SL, Su ZW, Wei M, Huang DH, Tian YQ, et al: Metadherin regulation
of vascular endothelial growth factor expression is dependent upon
the PI3K/Akt pathway in squamous cell carcinoma of the head and
neck. Medicine (Baltimore). 94:e5022015. View Article : Google Scholar : PubMed/NCBI
|
56
|
Liu H, Song X, Liu C, Xie L, Wei L and Sun
R: Knockdown of astrocyte elevated gene-1 inhibits proliferation
and enhancing chemo-sensitivity to cisplatin or doxorubicin in
neuroblastoma cells. J Exp Clin Cancer Res. 28:192009. View Article : Google Scholar : PubMed/NCBI
|