Open Access

MicroRNA-211 suppresses prostate cancer proliferation by targeting SPARC

  • Authors:
    • Peng Hao
    • Bo Kang
    • Guoqing Yao
    • Wenqi Hao
    • Feihong Ma
  • View Affiliations

  • Published online on: January 26, 2018     https://doi.org/10.3892/ol.2018.7877
  • Pages:4323-4329
  • Copyright: © Hao et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Dysregulation of microRNAs (miRNAs/miRs) is frequently associated with cancer progression. Altered expression of miR‑211 has been observed in various types of human cancer; however, its expression and role in prostate cancer (PCa) remains unknown. In the present study, the expression of miR‑211 in PCa cell lines and tissues was measured by reverse transcription‑quantitative PCR (qPCR), revealing that miR‑211 was downregulated in PCa cell lines and tissues. Further analysis revealed that low miR‑211 was associated with the tumor stage and Gleason score. With the assistance of miR‑211 mimics and inhibitor, it was also revealed that the overexpression of miR‑211 could inhibit PCa cell proliferation in vitro. Conversely, downregulated miR‑211 expression promotes PCa cell proliferation. In addition, the secreted protein acidic and rich in cysteine (SPARC) was identified as a target of miR‑211 in the PCa cell lines, and SPARC expression was inversely associated with miR‑211. In conclusion, it was demonstrated that the miR‑211 expression was downregulated in PCa cell lines and tissues. Additionally, miR‑211 could inhibit PCa cell proliferation partially by downregulating SPARC. Therefore, miR‑211 may be a potential therapeutic target for PCa treatment in the future.

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April 2018
Volume 15 Issue 4

Print ISSN: 1792-1074
Online ISSN:1792-1082

2016 Impact Factor: 1.39
Ranked #68/217 Oncology
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APA
Hao, P., Kang, B., Yao, G., Hao, W., & Ma, F. (2018). MicroRNA-211 suppresses prostate cancer proliferation by targeting SPARC. Oncology Letters, 15, 4323-4329. https://doi.org/10.3892/ol.2018.7877
MLA
Hao, P., Kang, B., Yao, G., Hao, W., Ma, F."MicroRNA-211 suppresses prostate cancer proliferation by targeting SPARC". Oncology Letters 15.4 (2018): 4323-4329.
Chicago
Hao, P., Kang, B., Yao, G., Hao, W., Ma, F."MicroRNA-211 suppresses prostate cancer proliferation by targeting SPARC". Oncology Letters 15, no. 4 (2018): 4323-4329. https://doi.org/10.3892/ol.2018.7877