Increased expression of high-mobility group nucleosomal-binding domain 2 protein in various tumor cell lines

  • Authors:
    • Qian Li
    • Jiao Chen
    • Xiaoying Li
    • Bomiao Cui
    • Yaping Fan
    • Ning Geng
    • Qianming Chen
    • Ping Zhang
    • Yun Feng
  • View Affiliations

  • Published online on: January 29, 2018     https://doi.org/10.3892/ol.2018.7898
  • Pages: 4517-4522
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Abstract

High mobility group nucleosomal-binding domain 2 (HMGN2) is an abundant non-histone nuclear protein of vertebrates and invertebrates. The aim of the present study was to characterize the endogenous expression of HMGN2 in various types of tumor cell. Western blotting was performed to analyze HMGN2 expression in the following tumor cell lines: H1975, HSC‑4, MDA‑MB‑468, MDA‑MB‑231, SCC‑25 and THP‑1. Periodontal ligament cells (PDLCs) were included as a noncancerous control. HMGN2 was detected in human oral squamous cell carcinoma tissues by immunohistochemical analysis. The results demonstrated that the expression of HMGN2 was increased in the majority of tumor cell lines, particularly MDA‑MB‑468 and THP‑1 cells, compared with PDLCs. The expression of HMGN2 in oral squamous cell carcinoma tissue was significantly increased compared with the expression in normal tissue. Furthermore, the expression of HMGN2 in metastatic oral squamous cell carcinoma tissues was increased compared with that in its non‑metastatic counterpart. These results indicated that HMGN2 may serve an important function in the growth and metastasis of tumor cells.

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April 2018
Volume 15 Issue 4

Print ISSN: 1792-1074
Online ISSN:1792-1082

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APA
Li, Q., Chen, J., Li, X., Cui, B., Fan, Y., Geng, N. ... Feng, Y. (2018). Increased expression of high-mobility group nucleosomal-binding domain 2 protein in various tumor cell lines. Oncology Letters, 15, 4517-4522. https://doi.org/10.3892/ol.2018.7898
MLA
Li, Q., Chen, J., Li, X., Cui, B., Fan, Y., Geng, N., Chen, Q., Zhang, P., Feng, Y."Increased expression of high-mobility group nucleosomal-binding domain 2 protein in various tumor cell lines". Oncology Letters 15.4 (2018): 4517-4522.
Chicago
Li, Q., Chen, J., Li, X., Cui, B., Fan, Y., Geng, N., Chen, Q., Zhang, P., Feng, Y."Increased expression of high-mobility group nucleosomal-binding domain 2 protein in various tumor cell lines". Oncology Letters 15, no. 4 (2018): 4517-4522. https://doi.org/10.3892/ol.2018.7898