Antitumor activity of kinetochore-associated protein 2 siRNA against lung cancer patient-derived tumor xenografts

  • Authors:
    • Yukimasa Makita
    • Mika Teratani
    • Shumpei Murata
    • Yasutaka Hoashi
    • Satoru Matsumoto
    • Yuji Kawamata
  • View Affiliations

  • Published online on: January 29, 2018     https://doi.org/10.3892/ol.2018.7890
  • Pages: 4676-4682
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Abstract

It has been widely reported that patient-derived tumor xenografts (PDXs) are more similar to tumor tissues than conventional cancer cell lines. Kinetochore‑associated protein 2 (KNTC2) is known to be upregulated specifically in tumor tissues of cancer patients and is recognized as a potential target for cancer therapy. Previously, in vivo antitumor activities of KNTC2 short interfering RNA encapsulated into a lipid nanoparticle (KNTC2‑LNP) were reported in orthotopic hepatocellular carcinoma mouse models. However, it remains unclear whether KNTC2‑LNP exhibits antitumor activities against lung cancer PDXs. In the present study, the antitumor activities of KNTC2‑LNP were clarified in a three-dimensional culture system and a subcutaneous tumor model of lung cancer PDX, LC‑60, which was resistant to erlotinib. Growth inhibitory activities of KNTC2‑LNP were associated with knockdown activities. Furthermore, KNTC2‑LNP also exhibited in vivo antitumor activity against another lung cancer PDX, LC‑45, which was sensitive to erlotinib. These results suggest that KNTC2 is a promising target for patients with lung cancer.

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April 2018
Volume 15 Issue 4

Print ISSN: 1792-1074
Online ISSN:1792-1082

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APA
Makita, Y., Teratani, M., Murata, S., Hoashi, Y., Matsumoto, S., & Kawamata, Y. (2018). Antitumor activity of kinetochore-associated protein 2 siRNA against lung cancer patient-derived tumor xenografts. Oncology Letters, 15, 4676-4682. https://doi.org/10.3892/ol.2018.7890
MLA
Makita, Y., Teratani, M., Murata, S., Hoashi, Y., Matsumoto, S., Kawamata, Y."Antitumor activity of kinetochore-associated protein 2 siRNA against lung cancer patient-derived tumor xenografts". Oncology Letters 15.4 (2018): 4676-4682.
Chicago
Makita, Y., Teratani, M., Murata, S., Hoashi, Y., Matsumoto, S., Kawamata, Y."Antitumor activity of kinetochore-associated protein 2 siRNA against lung cancer patient-derived tumor xenografts". Oncology Letters 15, no. 4 (2018): 4676-4682. https://doi.org/10.3892/ol.2018.7890