Interleukin-37: A crucial cytokine with multiple roles in disease and potentially clinical therapy (Review)
- Lijuan Wang
- Yanchun Quan
- Yongfang Yue
- Xueyuan Heng
- Fengyuan Che
Published online on: February 7, 2018
Interleukin (IL)-37, a new IL-1 family member, has received increasing attention in recent years. In the past decade, it has been determined that IL‑37 is expressed in various normal cells and tissues and is regulated by inflammatory stimuli and pro‑cytokines via different signal transduction pathways. Recently, it has been found that IL‑37 is expressed in a variety of cancers, chronic inflammatory and autoimmune disorders, and exerts anti‑inflammatory effects. Moreover, a growing body of literature demonstrates that IL‑37 plays a vital role in inhibiting both innate and adaptive immune responses as well as inflammatory reactions. In addition, IL‑37 may prove to be a new and potentially useful target for effective cytokine therapy. Further evidence is needed to clarify in more detail the effects of IL‑37 in experimental and clinical studies. Based on an extensive summary of published data, the aim of this review is to outline the current knowledge of IL‑37, including the location, structure, expression, regulation and function, as well as the potential clinical applications of this cytokine.