Association of BCSC-1 and MMP-14 with human breast cancer
- Dalin Di
- Lei Chen
- Yingying Guo
- Lina Wang
- Huidong Wang
- Jiyu Ju
Published online on: February 6, 2018
Copyright: © Di et al.
This is an open access article distributed under the terms of Creative Commons Attribution License.
Breast cancer suppressor candidate-1 (BCSC-1) is a candidate tumor suppressor gene that was identified recently. Decreased levels of BCSC‑1 have been detected in a variety of cancer types in previous studies. Matrix metalloproteinase (MMP)‑14 is a membrane‑type MMP that plays an important role in tumor progression and prognosis. Previous research has indicated that MMP‑14 is highly expressed in different cancer types and promotes tumor invasion or metastasis by remodeling the extracellular matrix. However, there have been few reports on BCSC‑1 and MMP‑14 in human breast cancer in recent years. In the present study, the association of BCSC‑1 and MMP‑14 with human breast cancer was investigated. The immunohistochemical analysis results revealed reduced expression of BCSC‑1 and overexpression of MMP‑14 in breast cancer tissues compared with adjacent normal breast tissues. Quantitative polymerase chain reaction and western blot analyses also showed that BCSC‑1 was expressed at significantly lower levels, and that MMP‑14 was expressed at significantly higher levels in breast cancer tissues compared with healthy breast tissue. Furthermore, decreased expression of BCSC‑1 and overexpression of MMP‑14 were associated with tumor cellular differentiation, lymph node metastasis and distant metastasis. A correlational analysis between BCSC‑1 and MMP‑14 was also conducted, and the results indicated a negative correlation between the two. In conclusion, the current findings indicate that BCSC‑1 is downregulated, while MMP‑14 is overexpressed in human breast cancer. These two genes may play important roles during the process of human breast cancer development.