Ras‑related protein Rap2c promotes the migration and invasion of human osteosarcoma cells Corrigendum in /10.3892/ol.2021.12723

Wu,Jinxia; Du,Wenqi; Wang,Xiucun; Wei,Lulu; Pan,Yaojie; Wu,Xiaojin; Zhang,Jinling; Pei,Dongsheng

doi:10.3892/ol.2018.7987

Ras‑related protein Rap2c promotes the migration and invasion of human osteosarcoma cells

Corrigendum in: /10.3892/ol.2021.12723

Authors:
- Jinxia Wu
- Wenqi Du
- Xiucun Wang
- Lulu Wei
- Yaojie Pan
- Xiaojin Wu
- Jinling Zhang
- Dongsheng Pei
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Affiliations: Department of Physiology, Xuzhou Medical University, Xuzhou, Jiangsu 221004, P.R. China, Jiangsu Key Laboratory of Biological Cancer Therapy, Xuzhou, Jiangsu 221002, P.R. China, Department of Neurosurgery, The Affiliated Hospital of Xuzhou Medical University, Xuzhou, Jiangsu 221000, P.R. China, Department of Pathology, Xuzhou Medical University, Xuzhou, Jiangsu 221004, P.R. China, Department of Radiation Oncology, The First People's Hospital of Xuzhou, Xuzhou, Jiangsu 221002, P.R. China, Department of Oncology, LinYi People's Hospital Affiliated to Shandong University, Jinan, Shandong 250012, P.R. China
Published online on: February 7, 2018 https://doi.org/10.3892/ol.2018.7987
Pages: 5352-5358

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Abstract

Ras-related protein (Rap)2a and Rap2b are members of the GTP‑binding protein family, and serve an important function in tumor progression. However, the associations between Rap2c and cancer cell functions have not yet been reported. Osteosarcoma is a type of bone cancer; its high degree of invasion is considered to be a major treatment challenge. The present study first investigated the biological role of Rap2c in human osteosarcoma cells and investigated the underlying mechanism of Rap2c on osteosarcoma cell migration and invasion. The results of the present study demonstrated that Rap2c overexpression promoted the migratory and invasive ability of cancer cells, and increased the activity of matrix metalloproteinase‑2 (MMP2). Correspondingly, the knockdown of Rap2c inhibited tumor cell migration and invasion, whereas alterations to Rap2c had no effect on osteosarcoma cell proliferation or rate of apoptosis. Furthermore, Rap2c overexpression may decrease the protein level of tissue inhibitor of metalloproteinases 2 and increase the phosphorylation level of protein kinase B (Akt). Collectively, these results indicated that Rap2c has a key function in tumor migration and invasion, and the Akt signaling pathway may be involved in Rap2c‑induced MMP2 expression.

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