Anthelmintic pyrvinium pamoate blocks Wnt/β-catenin and induces apoptosis in multiple myeloma cells

Corrigendum in: /10.3892/ol.2020.12110

  • Authors:
    • Fang Xu
    • Yingjie Zhu
    • Yuhong Lu
    • Zhi Yu
    • Jun Zhong
    • Yangqiu Li
    • Jingxuan Pan
  • View Affiliations

  • Published online on: February 9, 2018     https://doi.org/10.3892/ol.2018.8006
  • Pages: 5871-5878
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Abstract

Multiple myeloma (MM) is a malignancy of the bone marrow. The median survival time of patients with MM is only 5 years, with patients frequently experiencing relapse. Currently, there is no effective therapy for recurrent MM. The results of the present study indicated that pyrvinium pamoate (PP), a US Food and Drug Administration‑approved oral anthelmintic drug, exhibited potent antitumor activity in MM cells in vitro. It is demonstrated that PP inhibited MM cell proliferation and mediated apoptosis. Notably, PP markedly promoted the degradation of β‑catenin and abrogated its phosphorylation. PP triggered apoptosis in MM cells by inducing the release of cytochrome c and downregulating the expression of myeloid leukemia cell differentiation protein. In addition, PP effectively induced cell death in primary MM cells. In conclusion, PP may be a promising agent for the clinical treatment of MM.
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April-2018
Volume 15 Issue 4

Print ISSN: 1792-1074
Online ISSN:1792-1082

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Spandidos Publications style
Xu F, Zhu Y, Lu Y, Yu Z, Zhong J, Li Y and Pan J: Anthelmintic pyrvinium pamoate blocks Wnt/β-catenin and induces apoptosis in multiple myeloma cells Corrigendum in /10.3892/ol.2020.12110. Oncol Lett 15: 5871-5878, 2018
APA
Xu, F., Zhu, Y., Lu, Y., Yu, Z., Zhong, J., Li, Y., & Pan, J. (2018). Anthelmintic pyrvinium pamoate blocks Wnt/β-catenin and induces apoptosis in multiple myeloma cells Corrigendum in /10.3892/ol.2020.12110. Oncology Letters, 15, 5871-5878. https://doi.org/10.3892/ol.2018.8006
MLA
Xu, F., Zhu, Y., Lu, Y., Yu, Z., Zhong, J., Li, Y., Pan, J."Anthelmintic pyrvinium pamoate blocks Wnt/β-catenin and induces apoptosis in multiple myeloma cells Corrigendum in /10.3892/ol.2020.12110". Oncology Letters 15.4 (2018): 5871-5878.
Chicago
Xu, F., Zhu, Y., Lu, Y., Yu, Z., Zhong, J., Li, Y., Pan, J."Anthelmintic pyrvinium pamoate blocks Wnt/β-catenin and induces apoptosis in multiple myeloma cells Corrigendum in /10.3892/ol.2020.12110". Oncology Letters 15, no. 4 (2018): 5871-5878. https://doi.org/10.3892/ol.2018.8006