Open Access

The potential function of microRNAs as biomarkers and therapeutic targets in multiple myeloma (Review)

  • Authors:
    • Bingying Zhu
    • Shaoqing Ju
    • Haidan Chu
    • Xianjuan Shen
    • Yan Zhang
    • Xi Luo
    • Hui Cong
  • View Affiliations

  • Published online on: March 2, 2018     https://doi.org/10.3892/ol.2018.8157
  • Pages: 6094-6106
  • Copyright: © Zhu et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Multiple myeloma (MM), accounting for ~1% of all types of human cancer and 13% of all hematological malignancies, is characterized by the malignant proliferation of monoclonal plasma cells (PCs) in the bone marrow. MM leads to end stage organ impairment, including bone lesions, renal dysfunction, hypercalcemia and anemia. So far, the specific pathogenesis of MM remains unclear and no early‑stage sensitive biomarker of MM has been well characterized. Furthermore, treating MM is difficult, as the majority of patients eventually relapse or become refractory following treatment using presently available methods. To date, a number of studies have demonstrated that microRNAs (miRNAs) may serve crucial functions in the progression of numerous cancers, including MM. During the tumorigenesis and pathogenesis of MM, there are multiple carcinogenic events that involve the pernicious transformation from normal to malignant PCs. miRNAs, as oncogenes or tumor suppressors, regulate MM progression‑related signaling pathways. In the present review, the up‑to‑date preliminary basic studies and associated clinical works on the underlying mechanisms of aberrant miRNA profiling in MM have been summarized, including an evaluation of its value as a potential biomarker and a novel therapeutic strategy for MM.
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May-2018
Volume 15 Issue 5

Print ISSN: 1792-1074
Online ISSN:1792-1082

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Copy and paste a formatted citation
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Spandidos Publications style
Zhu B, Ju S, Chu H, Shen X, Zhang Y, Luo X and Cong H: The potential function of microRNAs as biomarkers and therapeutic targets in multiple myeloma (Review). Oncol Lett 15: 6094-6106, 2018
APA
Zhu, B., Ju, S., Chu, H., Shen, X., Zhang, Y., Luo, X., & Cong, H. (2018). The potential function of microRNAs as biomarkers and therapeutic targets in multiple myeloma (Review). Oncology Letters, 15, 6094-6106. https://doi.org/10.3892/ol.2018.8157
MLA
Zhu, B., Ju, S., Chu, H., Shen, X., Zhang, Y., Luo, X., Cong, H."The potential function of microRNAs as biomarkers and therapeutic targets in multiple myeloma (Review)". Oncology Letters 15.5 (2018): 6094-6106.
Chicago
Zhu, B., Ju, S., Chu, H., Shen, X., Zhang, Y., Luo, X., Cong, H."The potential function of microRNAs as biomarkers and therapeutic targets in multiple myeloma (Review)". Oncology Letters 15, no. 5 (2018): 6094-6106. https://doi.org/10.3892/ol.2018.8157