Open Access

Liver regeneration during the associating liver partition and portal vein ligation for staged hepatectomy procedure in Sus scrofa is positively modulated by stem cells

  • Authors:
    • Martin Bartas
    • Jiri Červeň
    • Jan Oppelt
    • Matus Peteja
    • Petr Vávra
    • Pavel Zonča
    • Vaclav Procházka
    • Vaclav Brázda
    • Petr Pečinka
  • View Affiliations

  • Published online on: February 22, 2018     https://doi.org/10.3892/ol.2018.8108
  • Pages: 6309-6321
  • Copyright: © Bartas et al. This is an open access article distributed under the terms of Creative Commons Attribution License [CC BY_NC 4.0].

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Abstract

This present study investigated the impact of the application of stem cells to liver regeneration following the first stage of associating liver partition and portal vein ligation for staged hepatectomy (ALPPS). The experiment was conducted on a pig model (n=6, 3 that did not receive application of stem cells, 3 that received application stem cells). Collected samples of liver (day 0 and 9 following surgery) were subjected to complete transcriptome sequencing. In total, 39 differentially expressed genes were found in the group without the application of the stem cells (genes of unwanted processes such as fibrosis and inflammation). In the group that did receive application of stem cells, no significantly differentially expressed genes were found, indicating a properly regenerated liver remnant. The present study therefore demonstrated, to the best of our knowledge for the first time, the positive effect of stem cells application in the liver regeneration process during ALPPS procedure in the pig model.
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May-2018
Volume 15 Issue 5

Print ISSN: 1792-1074
Online ISSN:1792-1082

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Spandidos Publications style
Bartas M, Červeň J, Oppelt J, Peteja M, Vávra P, Zonča P, Procházka V, Brázda V and Pečinka P: Liver regeneration during the associating liver partition and portal vein ligation for staged hepatectomy procedure in Sus scrofa is positively modulated by stem cells. Oncol Lett 15: 6309-6321, 2018
APA
Bartas, M., Červeň, J., Oppelt, J., Peteja, M., Vávra, P., Zonča, P. ... Pečinka, P. (2018). Liver regeneration during the associating liver partition and portal vein ligation for staged hepatectomy procedure in Sus scrofa is positively modulated by stem cells. Oncology Letters, 15, 6309-6321. https://doi.org/10.3892/ol.2018.8108
MLA
Bartas, M., Červeň, J., Oppelt, J., Peteja, M., Vávra, P., Zonča, P., Procházka, V., Brázda, V., Pečinka, P."Liver regeneration during the associating liver partition and portal vein ligation for staged hepatectomy procedure in Sus scrofa is positively modulated by stem cells". Oncology Letters 15.5 (2018): 6309-6321.
Chicago
Bartas, M., Červeň, J., Oppelt, J., Peteja, M., Vávra, P., Zonča, P., Procházka, V., Brázda, V., Pečinka, P."Liver regeneration during the associating liver partition and portal vein ligation for staged hepatectomy procedure in Sus scrofa is positively modulated by stem cells". Oncology Letters 15, no. 5 (2018): 6309-6321. https://doi.org/10.3892/ol.2018.8108