Open Access

MicroRNA-192-5p suppresses the initiation and progression of osteosarcoma by targeting USP1

  • Authors:
    • Sheng Zhou
    • Min Xiong
    • Guo Dai
    • Ling Yu
    • Zhengpei Zhang
    • Jie Chen
    • Weichun Guo
  • View Affiliations

  • Published online on: March 6, 2018     https://doi.org/10.3892/ol.2018.8180
  • Pages: 6947-6956
  • Copyright: © Zhou et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Osteosarcoma is the most frequent primary malignant bone tumor. An increasing body of evidence has suggested that microRNAs (miRNA/miRs) have emerged as critical regulators in the initiation and progression of osteosarcoma. The present study explored the biological function of miR‑192‑5p and ubiquitin‑specific protease 1 (USP1), and investigated whether miR‑192‑5p could directly interact with USP1 in osteosarcoma. The results revealed that miR‑192‑5p was significantly downregulated in osteosarcoma tissues and cell lines, while a reverse expression profile of USP1 was observed. Ectopic expression of miR‑192‑5p restrained cell proliferation, apoptosis, migration and invasion. In addition, it increased the sensitivity of osteosarcoma cells to cisplatin. USP1 was also observed to be a direct target gene of miR‑192‑5p in osteosarcoma. Overexpression of USP1 promoted cell proliferation, apoptosis, migration and invasion, and decreased cell chemo‑sensitivity; however, it could be partially reversed via the overexpression of miR‑192‑5p in osteosarcoma cell lines. Taken together, the present study demonstrated that miR‑192‑5p suppressed the initiation and progression of osteosarcoma by targeting USP1. Therefore, miR‑192‑5p may serve as a valuable biomarker and the miR‑192‑5p/USP1 axis may function as a novel therapeutic target for osteosarcoma.
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May-2018
Volume 15 Issue 5

Print ISSN: 1792-1074
Online ISSN:1792-1082

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Spandidos Publications style
Zhou S, Xiong M, Dai G, Yu L, Zhang Z, Chen J and Guo W: MicroRNA-192-5p suppresses the initiation and progression of osteosarcoma by targeting USP1. Oncol Lett 15: 6947-6956, 2018.
APA
Zhou, S., Xiong, M., Dai, G., Yu, L., Zhang, Z., Chen, J., & Guo, W. (2018). MicroRNA-192-5p suppresses the initiation and progression of osteosarcoma by targeting USP1. Oncology Letters, 15, 6947-6956. https://doi.org/10.3892/ol.2018.8180
MLA
Zhou, S., Xiong, M., Dai, G., Yu, L., Zhang, Z., Chen, J., Guo, W."MicroRNA-192-5p suppresses the initiation and progression of osteosarcoma by targeting USP1". Oncology Letters 15.5 (2018): 6947-6956.
Chicago
Zhou, S., Xiong, M., Dai, G., Yu, L., Zhang, Z., Chen, J., Guo, W."MicroRNA-192-5p suppresses the initiation and progression of osteosarcoma by targeting USP1". Oncology Letters 15, no. 5 (2018): 6947-6956. https://doi.org/10.3892/ol.2018.8180