Role of interleukin‑32 in cancer biology (Review)

  • Authors:
    • Haimeng Yan
    • Donghua He
    • Xi Huang
    • Enfan Zhang
    • Qingxiao Chen
    • Ruyi Xu
    • Xinling Liu
    • Fuming Zi
    • Zhen Cai
  • View Affiliations

  • Published online on: May 7, 2018     https://doi.org/10.3892/ol.2018.8649
  • Pages: 41-47
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Abstract

Interleukin‑32 (IL‑32), a novel proinflammatory cytokine, is highly expressed in various cancer tissues and in established cancer cell lines. IL‑32 has been revealed to serve a crucial role in human cancer development, including tumour initiation, proliferation and maintenance. The expression of IL‑32 is regulated by numerous factors, including genetic variations, hypoxia and acidosis in the tumour microenvironment. Understanding the underlying mechanisms of IL‑32 expression and its function are critical for the discovery of novel therapeutic strategies that target IL‑32. This is a review of the current literature on the regulation and function of IL‑32 in cancer progression, focusing on the molecular pathways linking IL‑32 and tumour development.
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July-2018
Volume 16 Issue 1

Print ISSN: 1792-1074
Online ISSN:1792-1082

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Copy and paste a formatted citation
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Spandidos Publications style
Yan H, He D, Huang X, Zhang E, Chen Q, Xu R, Liu X, Zi F and Cai Z: Role of interleukin‑32 in cancer biology (Review). Oncol Lett 16: 41-47, 2018
APA
Yan, H., He, D., Huang, X., Zhang, E., Chen, Q., Xu, R. ... Cai, Z. (2018). Role of interleukin‑32 in cancer biology (Review). Oncology Letters, 16, 41-47. https://doi.org/10.3892/ol.2018.8649
MLA
Yan, H., He, D., Huang, X., Zhang, E., Chen, Q., Xu, R., Liu, X., Zi, F., Cai, Z."Role of interleukin‑32 in cancer biology (Review)". Oncology Letters 16.1 (2018): 41-47.
Chicago
Yan, H., He, D., Huang, X., Zhang, E., Chen, Q., Xu, R., Liu, X., Zi, F., Cai, Z."Role of interleukin‑32 in cancer biology (Review)". Oncology Letters 16, no. 1 (2018): 41-47. https://doi.org/10.3892/ol.2018.8649