Upregulation of circ_001569 predicts poor prognosis and promotes cell proliferation in non‑small cell lung cancer by regulating the Wnt/β‑catenin pathway

  • Authors:
    • Lingchi Ding
    • Weidong Yao
    • Junguo Lu
    • Jun Gong
    • Xiaodong Zhang
  • View Affiliations

  • Published online on: May 8, 2018     https://doi.org/10.3892/ol.2018.8673
  • Pages: 453-458
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Abstract

Circular RNAs (circRNAs) are a large class of RNAs that have previously been identified to be involved in certain diseases, including the development of cancer. However, the role of circ_001569 in non‑small cell lung cancer (NSCLC) remains unknown. In the present study, it was demonstrated that expression levels of circ_001569 were significantly increased in NSCLC tissues compared with in adjacent normal tissues. Increased circ_001569 expression was closely associated with tumor differentiation, lymph node metastasis and Tumor‑Node‑Metastasis classification in NSCLC. Patients that exhibited higher circ_001569 expression demonstrated a poorer survival outcome compared with patients with lower circ_001569 expression. Functional assay results indicated that the knockdown of circ_001569 inhibited the cell proliferation ability of NSCLC in vitro. In addition, it was identified that circ_001569 knockdown reduced the mRNA and protein expression levels of Wnt/β‑catenin pathway‑associated genes proto‑oncogene protein Wnt1, transcription factor 4 and β‑catenin in NSCLC cells. Therefore, the results indicated that circ_001569 promoted cell proliferation by regulating the Wnt/β‑catenin pathway in NSCLC, and circ_001569 may be a potential target of NSCLC treatment.
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July-2018
Volume 16 Issue 1

Print ISSN: 1792-1074
Online ISSN:1792-1082

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Spandidos Publications style
Ding L, Yao W, Lu J, Gong J and Zhang X: Upregulation of circ_001569 predicts poor prognosis and promotes cell proliferation in non‑small cell lung cancer by regulating the Wnt/β‑catenin pathway. Oncol Lett 16: 453-458, 2018.
APA
Ding, L., Yao, W., Lu, J., Gong, J., & Zhang, X. (2018). Upregulation of circ_001569 predicts poor prognosis and promotes cell proliferation in non‑small cell lung cancer by regulating the Wnt/β‑catenin pathway. Oncology Letters, 16, 453-458. https://doi.org/10.3892/ol.2018.8673
MLA
Ding, L., Yao, W., Lu, J., Gong, J., Zhang, X."Upregulation of circ_001569 predicts poor prognosis and promotes cell proliferation in non‑small cell lung cancer by regulating the Wnt/β‑catenin pathway". Oncology Letters 16.1 (2018): 453-458.
Chicago
Ding, L., Yao, W., Lu, J., Gong, J., Zhang, X."Upregulation of circ_001569 predicts poor prognosis and promotes cell proliferation in non‑small cell lung cancer by regulating the Wnt/β‑catenin pathway". Oncology Letters 16, no. 1 (2018): 453-458. https://doi.org/10.3892/ol.2018.8673