Caspase‑10, matrix metalloproteinase‑9 and total laminin are correlated with the tumor malignancy of clear cell renal cell carcinoma

Qian,Hua; Li,Xiaoguang; Zhang,Wei; Ma,Liang; Sun,Junfeng; Tang,Xianling; Chen,Yongsheng; Teng,Lichen; Wang,Wentao; Li,Dechao; Xu,Yongpeng; Li,Changfu; Cao,Yan

doi:10.3892/ol.2018.8845

Caspase‑10, matrix metalloproteinase‑9 and total laminin are correlated with the tumor malignancy of clear cell renal cell carcinoma

Authors:
- Hua Qian
- Xiaoguang Li
- Wei Zhang
- Liang Ma
- Junfeng Sun
- Xianling Tang
- Yongsheng Chen
- Lichen Teng
- Wentao Wang
- Dechao Li
- Yongpeng Xu
- Changfu Li
- Yan Cao
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Affiliations: Academician Workstation, Harbin Medical University and Heilongjiang Academy of Medical Sciences, Harbin, Heilongjiang 150081, P.R. China, Translational Medicine Research and Cooperation Center of Northern China, Heilongjiang Academy of Medical Sciences, Harbin, Heilongjiang 150081, P.R. China, Department of Cardiovascular Medicine, First Affiliated Hospital, Harbin Medical University, Harbin, Heilongjiang 150001, P.R. China, Eye Hospital, First Affiliated Hospital, Harbin Medical University, Harbin, Heilongjiang 150001, P.R. China, Department of Urology, Harbin Medical University Cancer Hospital, Harbin, Heilongjiang 150001, P.R. China
Published online on: May 30, 2018 https://doi.org/10.3892/ol.2018.8845
Pages: 2039-2045

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Abstract

Clear cell renal cell carcinoma (ccRCC) is a common malignant kidney tumor, the pathogenesis of which remains unclear. The aim of the present study was to investigate whether caspase‑10, matrix metalloproteinase‑9 (MMP‑9) and total laminin (LM) were involved into the pathogenesis of ccRCC. The levels of caspase‑10, MMP‑9 and total LM were analyzed by ELISA in tumor tissues and adjacent non‑malignant tissues of 27 patients with ccRCC. The results revealed that caspase‑10 levels in the tumor tissues were significantly higher than those in the adjacent non‑malignant tissues (P<0.05). The MMP‑9 levels in the tumor tissues were significantly lower than those in adjacent non‑malignant tissues (P<0.01). The total LM levels in tumor tissues revealed no statistical difference with those in the adjacent non‑malignant tissues (P=0.757). Additionally, caspase‑10 levels were positively correlated with MMP‑9 levels (P<0.001), but negatively correlated with total LM levels (P<0.05) in tumor tissues. Correlation analyses with clinical data of patients with ccRCC, revealed that caspase‑10 levels (P<0.05) and MMP‑9 levels (P<0.001) in tumor tissues were positively correlated with tumor grades of ccRCC, whereas total LM levels were positively correlated with tumor size (P<0.05). The results of the present study suggested that interactions between caspase‑10, MMP‑9 and LM are likely involved in the pathogenesis of ccRCC. A deeper understanding of the correlation between caspase‑10, MMP‑9 and LM would aid the clarification of pathogenesis of ccRCC.

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