Pathological tumor volume predicts survival outcomes in oral squamous cell carcinoma

Mukoyama,Nobuaki; Suzuki,Hidenori; Hanai,Nobuhiro; Sone,Michihiko; Hasegawa,Yasuhisa

doi:10.3892/ol.2018.8951

Pathological tumor volume predicts survival outcomes in oral squamous cell carcinoma

Authors:
- Nobuaki Mukoyama
- Hidenori Suzuki
- Nobuhiro Hanai
- Michihiko Sone
- Yasuhisa Hasegawa
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Affiliations: Department of Otorhinolaryngology, Nagoya University Graduate School of Medicine, Nagoya, Aichi 466‑8560, Japan, Department of Head and Neck Surgery, Aichi Cancer Center Hospital, Nagoya, Aichi 464‑8681, Japan
Published online on: June 12, 2018 https://doi.org/10.3892/ol.2018.8951
Pages: 2471-2477
Copyright: © Mukoyama et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

The present study examined whether the pathological tumor volume (PTV) was correlated with the survival outcomes in patients with oral squamous cell carcinoma (SCC) and clinical lymph node metastasis. Forty‑seven patients who underwent radical surgery without preoperative treatment were enrolled. The PTV of the primary tumor, which was surgically resected without preoperative treatment, was calculated based on the diameters in three dimensions. A survival analysis was performed using a Cox proportional hazards model. A PTV of ≥18 cm3 was significantly correlated with shorter overall survival (P<0.01) and local recurrence‑free survival (P<0.01) in a univariate analysis. A multivariate analysis with adjustment for the pathological stage (stage I‑II/III‑IV), primary site (tongue/others) and positive surgical margin and/or extracapsular extension (absent/present) showed that a PTV of ≥18 cm3 was significantly correlated with shorter overall survival (P<0.01) and local recurrence‑free survival (P<0.01). The present findings suggested that PTV in oral SCC provides a prognostic parameter that may predict shorter or longer overall and local recurrence‑free survival.

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