Circular RNA as a biomarker for cancer: A systematic meta‑analysis

  • Authors:
    • Yulong Li
    • Xiaoli Zeng
    • Jianxun He
    • Yuan Gui
    • Song Zhao
    • Hua Chen
    • Qi Sun
    • Nan Jia
    • Hui Yuan
  • View Affiliations

  • Published online on: July 11, 2018     https://doi.org/10.3892/ol.2018.9125
  • Pages: 4078-4084
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )


Abstract

Circular RNAs (circRNAs) may serve as biomarkers for a potentially non‑invasive diagnosis of cancer. To understand their diagnostic performance, a systematic meta‑analysis of the published literature was conducted to review the diagnostic efficiency of circRNAs in patients with cancer. Eligible studies published up to November 30, 2017, on PubMed and EMBASE, were selected for the meta‑analysis. All studies were carefully and independently reviewed by two researchers based on their titles and abstracts, following which full texts were perused for potential eligibility. All statistical analyses were performed by STATA 13.0 statistical software and Meta‑DiSc 1.4. A total of 10 eligible studies were included. The pooled diagnostic odds ratio was 7.265. The pooled sensitivity was 0.708 and the pooled specificity was 0.722. The positive likelihood and negative likelihood ratios were 2.483 and 0.372, respectively. The area under the curve was 0.793. circRNA was determined to be a notably effective assistant diagnostic biomarker for cancer.
View Figures
View References

Related Articles

Journal Cover

September-2018
Volume 16 Issue 3

Print ISSN: 1792-1074
Online ISSN:1792-1082

Sign up for eToc alerts

Recommend to Library

Copy and paste a formatted citation
x
Spandidos Publications style
Li Y, Zeng X, He J, Gui Y, Zhao S, Chen H, Sun Q, Jia N and Yuan H: Circular RNA as a biomarker for cancer: A systematic meta‑analysis. Oncol Lett 16: 4078-4084, 2018
APA
Li, Y., Zeng, X., He, J., Gui, Y., Zhao, S., Chen, H. ... Yuan, H. (2018). Circular RNA as a biomarker for cancer: A systematic meta‑analysis. Oncology Letters, 16, 4078-4084. https://doi.org/10.3892/ol.2018.9125
MLA
Li, Y., Zeng, X., He, J., Gui, Y., Zhao, S., Chen, H., Sun, Q., Jia, N., Yuan, H."Circular RNA as a biomarker for cancer: A systematic meta‑analysis". Oncology Letters 16.3 (2018): 4078-4084.
Chicago
Li, Y., Zeng, X., He, J., Gui, Y., Zhao, S., Chen, H., Sun, Q., Jia, N., Yuan, H."Circular RNA as a biomarker for cancer: A systematic meta‑analysis". Oncology Letters 16, no. 3 (2018): 4078-4084. https://doi.org/10.3892/ol.2018.9125