Open Access

Intensity‑modulated radiation therapy combined with concomitant temozolomide for brain metastases from lung adenocarcinoma

  • Authors:
    • Jinli Li
    • Xiaoyan Chai
    • Ying Cao
    • Xiaochu Hu
    • Hongyu Zhu
    • Jianping Wang
    • Yiwei Wu
  • View Affiliations

  • Published online on: July 18, 2018     https://doi.org/10.3892/ol.2018.9171
  • Pages: 4285-4290
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Abstract

Short‑term efficacy, adverse effects and the impact on quality of life (QoL) of a concomitant treatment with intensity‑modulated radiation therapy (IMRT) and temozolomide (TMZ) in patients with brain metastases (BMs) from lung adenocarcinoma were evaluated. This study sought to confirm the benefit of adding TMZ to IMRT in patients with BMs from lung adenocarcinoma. Nine patients were enrolled and received a dose of 30 Gy in 10 daily fractions to clinical tumor volume (CTV) according to IMRT, then additional dose of 9 Gy in 3 fractions of IMRT was delivered to gross tumor volume (GTV) only with concomitant TMZ (75 mg/m2/day) orally during RT for 3 weeks. One patient achieved complete response (CR) (11.1%), 6 patients obtained partial response (PR) (66.7%), and there were no patients in progression. Therefore, objective response (OR) reached 77.8%. The main adverse effects included neutropenia, anemia, vomiting, fatigue and dizziness. Grade ≥3 of hematologic toxicities did not occur. However, the other 9 patients who received only intensity‑modulated radiation had much worse results. The CR was 0, PR rate was 44.4%, OR rate was 44.4%. The results indicated that the benefit of adding TMZ to IMRT was confirmed in patients with BMs from lung adenocarcinoma. The treatment was active, a significant OR was observed, and achieved an improvement in QoL demonstrated by QoL grade (p<0.05).
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October-2018
Volume 16 Issue 4

Print ISSN: 1792-1074
Online ISSN:1792-1082

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Spandidos Publications style
Li J, Chai X, Cao Y, Hu X, Zhu H, Wang J and Wu Y: Intensity‑modulated radiation therapy combined with concomitant temozolomide for brain metastases from lung adenocarcinoma. Oncol Lett 16: 4285-4290, 2018
APA
Li, J., Chai, X., Cao, Y., Hu, X., Zhu, H., Wang, J., & Wu, Y. (2018). Intensity‑modulated radiation therapy combined with concomitant temozolomide for brain metastases from lung adenocarcinoma. Oncology Letters, 16, 4285-4290. https://doi.org/10.3892/ol.2018.9171
MLA
Li, J., Chai, X., Cao, Y., Hu, X., Zhu, H., Wang, J., Wu, Y."Intensity‑modulated radiation therapy combined with concomitant temozolomide for brain metastases from lung adenocarcinoma". Oncology Letters 16.4 (2018): 4285-4290.
Chicago
Li, J., Chai, X., Cao, Y., Hu, X., Zhu, H., Wang, J., Wu, Y."Intensity‑modulated radiation therapy combined with concomitant temozolomide for brain metastases from lung adenocarcinoma". Oncology Letters 16, no. 4 (2018): 4285-4290. https://doi.org/10.3892/ol.2018.9171