Expression levels of miR‑205 and miR‑506 in colon cancer tissuesand their relationships with clinicopathological features

Jing,Nan; Yin,Lili; Sun,Junxi; Cao,Zhongzheng; Mao,Weizheng

doi:10.3892/ol.2018.9146

Expression levels of miR‑205 and miR‑506 in colon cancer tissuesand their relationships with clinicopathological features

Authors:
- Nan Jing
- Lili Yin
- Junxi Sun
- Zhongzheng Cao
- Weizheng Mao
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Affiliations: Qingdao University, Qingdao, Shandong 266071, P.R. China, Department of Blood Purification, Weifang People's Hospital, Weifang, Shandong 261000, P.R. China, Department of Anorectal Surgery, Weifang People's Hospital, Weifang, Shandong 261000, P.R. China, Department of General Surgery, Qingdao Municipal Hospital, Qingdao, Shandong 266071, P.R. China
Published online on: July 13, 2018 https://doi.org/10.3892/ol.2018.9146
Pages: 4331-4336
Copyright: © Jing et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

The study intended to investigate the expression levels of micro ribonucleic acid (miR)‑205 and miR‑506 in colon cancer tissues and their relationships with clinicopathological features. The expression levels of miR‑205 and miR‑506 in colon cancer tissues and para‑carcinoma normal colonic mucosa tissues were detected via fluorescence reverse transcription quantitative polymerase chain reaction (RT‑qPCR), and the expression levels of the two miRNAs in plasma of colon cancer patients and healthy control population were also detected. Moreover, the relationships of the two miRNAs with clinicopathological features of patients with colon cancer were analyzed. The expression levels of the two miRNAs in colon cancer tissues were higher than those in para‑carcinoma normal colonic mucosa tissues, and also significantly higher in plasma of the colon cancer patients than those in the healthy control population. The differences were statistically significant (P<0.05). The expression level of miR‑205 was associated with tumor‑node‑metastasis (TNM) staging and lymph node metastasis, while the expression level of miR‑506 was associated with lymph node metastasis. The differences were statistically significant (P<0.05). The expression levels of miR‑205 in the colon cancer tissues and plasma in patients had no significant correlation (r=0.467, P=0.081). There was a positive correlation between the expression levels of miR‑506 in the colon cancer tissues and plasma in patients (r=0.599, P=0.038). The expression levels of miR‑205 and miR‑506 are upregulated in the colon cancer patients, both of which may be closely related to the occurrence and development of colon cancer, and may become potential tumor markers as well as relevant therapeutic targets.

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