Differential expressions of integrin‑linked kinase, β‑parvin and cofilin 1 in high‑fat diet induced prostate cancer progression in a transgenic mouse model

Hu,Meng‑Bo; Hu,Ji‑Meng; Jiang,Li‑Ren; Yang,Tian; Zhu,Wen‑Hui; Hu,Yun; Wu,Xiao‑Bo; Jiang,Hao‑Wen; Ding,Qiang

doi:10.3892/ol.2018.9276

Differential expressions of integrin‑linked kinase, β‑parvin and cofilin 1 in high‑fat diet induced prostate cancer progression in a transgenic mouse model

Authors:
- Meng‑Bo Hu
- Ji‑Meng Hu
- Li‑Ren Jiang
- Tian Yang
- Wen‑Hui Zhu
- Yun Hu
- Xiao‑Bo Wu
- Hao‑Wen Jiang
- Qiang Ding
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Affiliations: Department of Urology, Huashan Hospital, Fudan University, Shanghai 200040, P.R. China, Department of Pathology, Shanghai General Hospital, Shanghai Jiaotong University, School of Medicine, Shanghai 201620, P.R. China
Published online on: August 7, 2018 https://doi.org/10.3892/ol.2018.9276
Pages: 4945-4952
Copyright: © Hu et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

High‑fat diet induced obesity was associated with more aggressive prostate cancer. Recent research has demonstrated that integrin‑linked kinase (ILK), β‑parvin and downstream cofilin 1 jointly affected cancer progression. Meanwhile, these proteins were also involved in energy metabolism. Therefore, the present study was conducted to investigate the potential function of ILK, β‑parvin and cofilin 1 in the high‑fat diet‑induced progression of prostate cancer. Transgenic mice with prostate cancer were employed, fed with different diets and sacrificed at 20 and 28 weeks. Tumor differentiation, extracapsular extension and metastasis were compared between the groups. Expression levels of ILK, β‑parvin and cofilin 1 in prostate were evaluated by immunohistochemical analysis and determined by an immunoreactivity score. Public databases were applied for analysis and validation. It was detected that high‑fat diet feeding promoted cancer progression in transgenic mice with prostate cancer, with increased expressions of β‑parvin (P=0.038) and cofilin 1 (P=0.018). Higher expressions of ILK, β‑parvin and cofilin 1 were also associated with poorer cancer differentiation. Additionally, higher mRNA levels of CFL1 were correlated with a worse disease‑free survival in patients of certain subgroups from The Cancer Genome Atlas database. Further studies were warranted in discussing the potential roles of ILK, β‑parvin and cofilin 1 in high‑fat diet feeding induced progression of prostate cancer.

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