Association between IDH1/2 mutations and brain glioma grade

  • Authors:
    • Lei Deng
    • Pengju Xiong
    • Yunhui Luo
    • Xiao Bu
    • Suokai Qian
    • Wuzhao Zhong
    • Shunqing Lv
  • View Affiliations

  • Published online on: August 17, 2018     https://doi.org/10.3892/ol.2018.9317
  • Pages: 5405-5409
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Abstract

Isocitrate dehydrogenase 1/2 (IDH)1/2 mutations are frequently detected in glioma. The aim of the present study was to investigate the association between IDH1/2 mutations and glioma grades. The current study was retrospective and used samples from 206 patients with brain glioma and 9 patients with spinal cord glioma as a control. Patients were diagnosed and graded according to the World Health Organization classification of tumors of the central nervous system. The association of patient age with glioma grade was evaluated, and IDH1/2 mutations were also examined and analyzed in different grades. On average, brain glioma grade tended to increase with increasing patient age; patients with grade IV (primary) gliomas had a significantly higher mean age than those with grades I and II (P<0.05), and patients with grade II glioma had a significantly lower mean age than those with grade III (P<0.05). The majority of brain gliomas with mutations in IDH1/2 in grade II, II‑III and III occurred in adults, rather than adolescents. IDH1/2 mutations occurred most frequently in grade II, II‑III and III gliomas, and these mutation frequencies differed significantly between brain glioma grades (P<0.001). In summary, mutations in IDH1/2 were associated with grade II, II‑III and III brain gliomas, and possibly with the progression of brain glioma from grade II to grade III.
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October-2018
Volume 16 Issue 4

Print ISSN: 1792-1074
Online ISSN:1792-1082

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Spandidos Publications style
Deng L, Xiong P, Luo Y, Bu X, Qian S, Zhong W and Lv S: Association between IDH1/2 mutations and brain glioma grade. Oncol Lett 16: 5405-5409, 2018
APA
Deng, L., Xiong, P., Luo, Y., Bu, X., Qian, S., Zhong, W., & Lv, S. (2018). Association between IDH1/2 mutations and brain glioma grade. Oncology Letters, 16, 5405-5409. https://doi.org/10.3892/ol.2018.9317
MLA
Deng, L., Xiong, P., Luo, Y., Bu, X., Qian, S., Zhong, W., Lv, S."Association between IDH1/2 mutations and brain glioma grade". Oncology Letters 16.4 (2018): 5405-5409.
Chicago
Deng, L., Xiong, P., Luo, Y., Bu, X., Qian, S., Zhong, W., Lv, S."Association between IDH1/2 mutations and brain glioma grade". Oncology Letters 16, no. 4 (2018): 5405-5409. https://doi.org/10.3892/ol.2018.9317