Imaging features of primary spinal osseous tumors and their value in clinical diagnosis

Yang,Lili; Zhang,Shuquan; Gu,Rui; Peng,Chuangang; Wu,Minfei

doi:10.3892/ol.2018.9659

Imaging features of primary spinal osseous tumors and their value in clinical diagnosis

Authors:
- Lili Yang
- Shuquan Zhang
- Rui Gu
- Chuangang Peng
- Minfei Wu
View Affiliations

Affiliations: Department of Orthopaedics, The Second Hospital of Jilin University, Changchun, Jilin 130041, P.R. China, Department of Orthopaedics, Nankai Hospital, Tianjin 300100, P.R. China, Department of Orthopaedics, China-Japan Union Hospital of Jilin University, Changchun, Jilin 130033, P.R. China
Published online on: November 1, 2018 https://doi.org/10.3892/ol.2018.9659
Pages: 1089-1093
Copyright: © Yang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )

Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )

Cited By (CrossRef): 0 citations Loading Articles...

Abstract

This study explored the method of imaging diagnosis of primary spinal osseous tumors and the application value of imaging in clinical diagnosis. Sixty-nine patients with primary spinal osseous tumors who received treatment in Nankai Hospital from July 2016 to June 2017 were selected. All of them received X-ray, computed tomography (CT) and magnetic resonance imaging (MRI) examinations to analyze the imaging features of the three examination methods. Sensitivity (Sen), specificity (Spe), positive predictive value (PV+), negative predictive value (PV-) and accuracy (Acc) were compared. The consistency of the three examination methods in diagnosing primary spinal osseous tumors was analyzed. Sen, Acc and PV- of the three examination methods in diagnosing spinal osseous tumors had obvious differences. MRI showed the highest Sen (P<0.05). MRI had relatively high consistency with CT scan in diagnosing primary spinal osseous tumors, and κ-value was 0.72. CT scan and X-ray had obvious difference in diagnosing primary spinal osseous tumors (P<0.05). The consistency between CT scan and X-ray in diagnosing primary spinal osseous tumors was relatively low, and κ-value was 0.47. MRI and X-ray had obvious difference in diagnosing primary spinal osseous tumors (P<0.05). The consistency between MRI and X-ray in diagnosing primary spinal osseous tumors was relatively low, and κ-value was 0.41. X-ray examination is easy to operate with high resolution. CT scan has obvious advantages in displaying lesions with complex structure, many of which locate in overlapping sites. MRI has more advantages and higher accuracy in judging the scope of the tumor. CT and MRI examinations have obviously higher efficacy than X-ray in diagnosing primary spinal osseous tumors. They are conducive in improving the accuracy of diagnosing primary spinal osseous tumors.

View Figures

View References

1	Guzik G: Current incidence of different morphological types of malignant metastases to the spine based on magnetic resonance imaging. Ortop Traumatol Rehabil. 19:137–144. 2017. View Article : Google Scholar : PubMed/NCBI
2	Gupta PK, Misra S, Verma R, Soni N, Lamin JC, Mishra RK, Behari S and Kumar S: Primary intradural cervical spine melanocytoma: A rare tumor and review of literature. Neurol India. 65:653–657. 2017. View Article : Google Scholar : PubMed/NCBI
3	Yang P, Lin J, Liu H, Shen H and Yang HL: Primary bone mantle cell lymphomas with multiple vertebral compression fractures: A case report. Oncol Lett. 13:1288–1292. 2017. View Article : Google Scholar : PubMed/NCBI
4	Konovalov NA, Nazarenko AG, Asyutin DS, Onoprienko RA, Korolishin VA, Cherkiev IU, Martynova MA, Zakirov BA, Timonin SY and Kosyr'kova AV: The use of intraoperative neuroimaging tools and a navigation system in surgical treatment of primary and metastatic tumors of the spine. Vopr Neirokhir. 80:5–14. 2016.(In Russian). View Article : Google Scholar
5	Zhou Z, Wang X, Wu Z, Huang W and Xiao J: Epidemiological characteristics of primary spinal osseous tumors in Eastern China. World J Surg Oncol. 15:732017. View Article : Google Scholar : PubMed/NCBI
6	Tomasian A, Wallace A, Northrup B, Hillen TJ and Jennings JW: Spine cryoablation: Pain palliation and local tumor control for vertebral metastases. AJNR Am J Neuroradiol. 37:189–195. 2016. View Article : Google Scholar : PubMed/NCBI
7	Welte SE, Wiskemann J, Scharhag-Rosenberger F, Förster R, Bostel T, Bruckner T, Schlampp I, Meyerhof E, Sprave T, Nicolay NH, et al: Differentiated resistance training of the paravertebral muscles in patients with unstable spinal bone metastasis under concomitant radiotherapy: Study protocol for a randomized pilot trial. Trials. 18:1552017. View Article : Google Scholar : PubMed/NCBI
8	Sciubba DM, De la Garza Ramos R, Goodwin CR, Xu R, Bydon A, Witham TF, Gokaslan ZL and Wolinsky JP: Total en bloc spondylectomy for locally aggressive and primary malignant tumors of the lumbar spine. Eur Spine J. 25:4080–4087. 2016. View Article : Google Scholar : PubMed/NCBI
9	Boriani S, Gasbarrini A, Bandiera S, Ghermandi R and Lador R: Predictors for surgical complications of en bloc resections in the spine: Review of 220 cases treated by the same team. Eur Spine J. 25:3932–3941. 2016. View Article : Google Scholar : PubMed/NCBI
10	Kumar N, Zaw AS, Khoo BL, Nandi S, Lai Z, Singh G, Lim CT and Thiery JP: Intraoperative cell salvage in metastatic spine tumour surgery reduces potential for reinfusion of viable cancer cells. Eur Spine J. 25:4008–4015. 2016. View Article : Google Scholar : PubMed/NCBI
11	Tamam MÖ, Tamam C, Yıldırım D, Mülazımoğlu M and Kamalı G: Intramedullary spinal cord metastasis from malignant mesenchymal tumor: Detection with FDG-PET/CT. Mol Imaging Radionucl Ther. 24 Suppl 1:22–24. 2015. View Article : Google Scholar
12	Monserrate A, Zussman B, Ozpinar A, Niranjan A, Flickinger JC and Gerszten PC: Stereotactic radiosurgery for intradural spine tumors using cone-beam CT image guidance. Neurosurg Focus. 42:E112017. View Article : Google Scholar : PubMed/NCBI
13	Klinaki I, Al-Nahhas A, Soneji N and Win Z: 68Ga DOTATATE PET/CT uptake in spinal lesions and MRI correlation on a patient with neuroendocrine tumor: Potential pitfalls. Clin Nucl Med. 38:e449–e453. 2013. View Article : Google Scholar : PubMed/NCBI
14	Kobayashi K, Imagama S, Ando K, Hida T, Ito K, Tsushima M, Ishikawa Y, Matsumoto A, Morozumi M, Tanaka S, et al: Contrast MRI findings for spinal schwannoma as predictors of tumor proliferation and motor status. Spine. 42:E150–E155. 2017. View Article : Google Scholar : PubMed/NCBI
15	Mechl M, Šprláková-Puková A and Keřkovský M: CT and MRI of spinal tumors - Review and differential diagnosis of most common abnormalities. Cesk Radiol. 66:369–378. 2012.
16	Tarnoki DL, Tarnoki AD, Ohlmann-Knafo S and Pickuth D: Pattern of tumour spread of common primary tumours as seen on magnetic resonance imaging. Pathol Oncol Res. 22:79–85. 2016. View Article : Google Scholar : PubMed/NCBI
17	Chou CT, Chen RC, Lin WC, Ko CJ, Chen CB and Chen YL: Prediction of microvascular invasion of hepatocellular carcinoma: Preoperative CT and histopathologic correlation. AJR Am J Roentgenol. 203:W253–W259. 2014. View Article : Google Scholar : PubMed/NCBI
18	Sahinarslan A, Erbas G, Kocaman SA, Bas D, Akyel A, Karaer D, Ergun MA, Arac M and Boyaci B: Comparison of radiation-induced damage between CT angiography and conventional coronary angiography. Acta Cardiol. 68:291–297. 2013. View Article : Google Scholar : PubMed/NCBI
19	Ganten MK, Schuessler M, Bäuerle T, Muenter M, Schlemmer HP, Jensen A, Brand K, Dueck M, Dinkel J, Kopp-Schneider A, et al: The role of perfusion effects in monitoring of chemoradiotherapy of rectal carcinoma using diffusion-weighted imaging. Cancer Imaging. 13:548–556. 2013. View Article : Google Scholar : PubMed/NCBI
20	D'Andrea K, Dreyer J and Fahim DK: Utility of preoperative magnetic resonance imaging coregistered with intraoperative computed tomographic scan for the resection of complex tumors of the spine. World Neurosurg. 84:1804–1815. 2015. View Article : Google Scholar : PubMed/NCBI