Prospective analysis of the association between skeletal‑related events and quality of life in patients with advanced lung cancer (CSP‑HOR13)

  • Authors:
    • Hiroshi Kunikane
    • Isao Yokota
    • Nobuyuki Katakami
    • Koji Takeda
    • Koichi Takayama
    • Toshiyuki Sawa
    • Hiroshi Saito
    • Masao Harada
    • Soichiro Yokota
    • Kiyoshi Ando
    • Yuko Saito
    • Yasuo Ohashi
    • Kenji Eguchi
  • View Affiliations

  • Published online on: November 9, 2018     https://doi.org/10.3892/ol.2018.9680
  • Pages: 1320-1326
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )


Abstract

A prospective study has previously reported on the incidence of bone metastasis (BM) and skeletal‑related events (SREs) in patients with advanced lung cancer. The aim of the present study was to prospectively investigate how the quality of life (QOL) of patients with advanced lung cancer was affected by SREs. Patients with stage IIIB or IV non‑small cell lung cancer (NSCLC) or small cell lung cancer (SCLC) at any stage were followed up every four weeks to determine if they had developed SREs. QOL questionnaires were conducted at enrollment, at 3‑ and 12‑months later and at 1 month after the onset of SREs, using QOL scores including the EuroQOL‑5 Dimension (EQ‑5D), Functional Assessment of Cancer Therapy‑General (FACT‑G) and activities of daily living (ADL) scores obtained by the Barthel Index. A total of 274 patients were enrolled in the study. At enrollment the EQ‑5D and Barthel Index scores were lower in patients with SREs compared with patients without SREs. A chronological analysis revealed no statistically significant changes in either QOL or ADL in any of the patients. For 14 patients in whom QOL data was collected following the onset of SREs, the evaluation undertaken on the four subscales of the FACT‑G revealed a significant decline in emotional functioning following the onset of SREs.
View Figures
View References

Related Articles

Journal Cover

January-2019
Volume 17 Issue 1

Print ISSN: 1792-1074
Online ISSN:1792-1082

Sign up for eToc alerts

Recommend to Library

Copy and paste a formatted citation
x
Spandidos Publications style
Kunikane H, Yokota I, Katakami N, Takeda K, Takayama K, Sawa T, Saito H, Harada M, Yokota S, Ando K, Ando K, et al: Prospective analysis of the association between skeletal‑related events and quality of life in patients with advanced lung cancer (CSP‑HOR13). Oncol Lett 17: 1320-1326, 2019.
APA
Kunikane, H., Yokota, I., Katakami, N., Takeda, K., Takayama, K., Sawa, T. ... Eguchi, K. (2019). Prospective analysis of the association between skeletal‑related events and quality of life in patients with advanced lung cancer (CSP‑HOR13). Oncology Letters, 17, 1320-1326. https://doi.org/10.3892/ol.2018.9680
MLA
Kunikane, H., Yokota, I., Katakami, N., Takeda, K., Takayama, K., Sawa, T., Saito, H., Harada, M., Yokota, S., Ando, K., Saito, Y., Ohashi, Y., Eguchi, K."Prospective analysis of the association between skeletal‑related events and quality of life in patients with advanced lung cancer (CSP‑HOR13)". Oncology Letters 17.1 (2019): 1320-1326.
Chicago
Kunikane, H., Yokota, I., Katakami, N., Takeda, K., Takayama, K., Sawa, T., Saito, H., Harada, M., Yokota, S., Ando, K., Saito, Y., Ohashi, Y., Eguchi, K."Prospective analysis of the association between skeletal‑related events and quality of life in patients with advanced lung cancer (CSP‑HOR13)". Oncology Letters 17, no. 1 (2019): 1320-1326. https://doi.org/10.3892/ol.2018.9680