Open Access

Effect of interventional embolotherapy on FHIT and p16 expression in hepatocellular carcinoma patients

  • Authors:
    • Wei Xu
    • Xiaogai Qi
    • Xia Wang
    • Jize Sun
  • View Affiliations

  • Published online on: October 31, 2018     https://doi.org/10.3892/ol.2018.9648
  • Pages: 871-876
  • Copyright: © Xu et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Effects of interventional embolotherapy on the expression of fragile histidine triad (FHIT) and p16 in hepatocellular carcinoma (HCC) patients were investigated. Patients with primary HCC who were definitely diagnosed and treated in the Department of Gastroenterology in Qingdao Central Hospital from March 2014 to March 2016 were selected, and they underwent interventional embolotherapy. HCC and cancer‑adjacent tissues of the patients were harvested for immunohistochemical staining. The correlation between the expression levels of FHIT and p16 was analyzed at the gene and protein level. Clinical data were collected, and whether they were correlated with the expression of FHIT and p16 was investigated. The expression levels of FHIT and p16 in primary HCC tissues were remarkably lower than that in cancer‑adjacent tissues (P<0.05). In HCC tissues, FHIT expression was obviously positively correlated with p16 expression (Spearman's correlation coefficient, r=0.308; P=0.025). FHIT was related to HCC tumor‑node‑metastasis (TNM) staging, the differentiation degree in Edmondson‑Steiner grading, lymph node metastasis and portal vein thrombosis (P<0.05 in all comparisons), whereas, p16 was associated with tumor size and the differentiation degree in Edmondson‑Steiner grading (P<0.05 in all comparisons). The expression of FHIT and p16 genes and proteins in HCC tissues were obviously lower than those in cancer‑adjacent tissues (P<0.05 in all comparisons). FHIT and p16 genes, as tumor suppressor genes, inhibit the proliferation of HCC, and there is a positive correlation between them. The proteins of the FHIT and p16 can be used as new indicators for clinical detection, thus providing a new method for clinical diagnosis.
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January-2019
Volume 17 Issue 1

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Copy and paste a formatted citation
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Spandidos Publications style
Xu W, Qi X, Wang X and Sun J: Effect of interventional embolotherapy on FHIT and p16 expression in hepatocellular carcinoma patients. Oncol Lett 17: 871-876, 2019.
APA
Xu, W., Qi, X., Wang, X., & Sun, J. (2019). Effect of interventional embolotherapy on FHIT and p16 expression in hepatocellular carcinoma patients. Oncology Letters, 17, 871-876. https://doi.org/10.3892/ol.2018.9648
MLA
Xu, W., Qi, X., Wang, X., Sun, J."Effect of interventional embolotherapy on FHIT and p16 expression in hepatocellular carcinoma patients". Oncology Letters 17.1 (2019): 871-876.
Chicago
Xu, W., Qi, X., Wang, X., Sun, J."Effect of interventional embolotherapy on FHIT and p16 expression in hepatocellular carcinoma patients". Oncology Letters 17, no. 1 (2019): 871-876. https://doi.org/10.3892/ol.2018.9648