Combinatorial therapy of immune checkpoint and cancer pathways provides a novel perspective on ovarian cancer treatment (Review)

  • Authors:
    • Guyu Zhang
    • Chongdong Liu
    • Huiming Bai
    • Guangming Cao
    • Ran Cui
    • Zhengyu Zhang
  • View Affiliations

  • Published online on: January 8, 2019     https://doi.org/10.3892/ol.2019.9902
  • Pages: 2583-2591
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Abstract

An increasing number of studies have reported that immunotherapy serves a significant role in ovarian cancer treatment. In recent years, blockade of checkpoint pathways, including programmed death‑ligand 1 (PD‑L1)/programmed death‑1 and cytotoxic T‑lymphocyte‑associated protein 4, has demonstrated significant clinical and preclinical benefits in the treatment of ovarian cancer. Additionally, tumor‑associated angiogenesis and homologous recombination deficiency frequently occurs in patients with high‑grade ovarian cancer, which makes cancer cells more susceptible to targeted therapies, including therapies targeting poly (ADP‑ribose) polymerase inhibitor, and anti‑angiogenic approaches. Additionally, targeted therapy has been associated with elevated PD‑L1 expression in tumor cells, increased T‑cell infiltration in tumors and dendritic cell stimulation. This synergistic effect provides the rationale for the joint application of targeted therapy and immunotherapy. Checkpoint blockades are able to elicit durable antitumor immune reactions and complement the transient antitumor effect of targeted therapies. The current review discusses the underlying mechanism of these therapies and novel developments in combined therapy for the treatment of ovarian cancer.
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March-2019
Volume 17 Issue 3

Print ISSN: 1792-1074
Online ISSN:1792-1082

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Copy and paste a formatted citation
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Spandidos Publications style
Zhang G, Liu C, Bai H, Cao G, Cui R and Zhang Z: Combinatorial therapy of immune checkpoint and cancer pathways provides a novel perspective on ovarian cancer treatment (Review). Oncol Lett 17: 2583-2591, 2019
APA
Zhang, G., Liu, C., Bai, H., Cao, G., Cui, R., & Zhang, Z. (2019). Combinatorial therapy of immune checkpoint and cancer pathways provides a novel perspective on ovarian cancer treatment (Review). Oncology Letters, 17, 2583-2591. https://doi.org/10.3892/ol.2019.9902
MLA
Zhang, G., Liu, C., Bai, H., Cao, G., Cui, R., Zhang, Z."Combinatorial therapy of immune checkpoint and cancer pathways provides a novel perspective on ovarian cancer treatment (Review)". Oncology Letters 17.3 (2019): 2583-2591.
Chicago
Zhang, G., Liu, C., Bai, H., Cao, G., Cui, R., Zhang, Z."Combinatorial therapy of immune checkpoint and cancer pathways provides a novel perspective on ovarian cancer treatment (Review)". Oncology Letters 17, no. 3 (2019): 2583-2591. https://doi.org/10.3892/ol.2019.9902