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Article

Molecular mechanism of triple‑negative breast cancer‑associated BRCA1 and the identification of signaling pathways

  • Authors:
    • Feng Qi
    • Wen‑Xing Qin
    • Yuan‑Sheng Zang
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    Affiliations: Department of Oncology, Changzheng Hospital, Second Military Medical University, Shanghai 200003, P.R. China
  • Pages: 2905-2914
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    Published online on: January 3, 2019
       https://doi.org/10.3892/ol.2019.9884
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Abstract

BRAC1 has multiple important interactions with triple‑negative breast cancer, the specific molecular characteristics of this interaction, however, have not yet been completely elucidated. By examining cell signaling pathways, important information for comprehending the potential mechanisms of this cancer may become known. The aim of the present study was to identify the effects of BRAC1 and to find the signaling pathway(s) involved in the pathogenic mechanism of triple‑negative breast cancer. In this study, GSE27447 microarray data were obtained from the Gene Expression Omnibus (GEO) database of the National Center for Biotechnology Information, and differentially expressed genes (DEGs) from GSE27447 were distinguished by Significant Analysis of Microarray. Gene ontology (GO) analysis was carried out on 132 upregulated and 198 downregulated genes with DAVID. The signaling was forecast by the Kyoto Encyclopedia of Genes and Genomes (KEGG). Transcription factors were recognized by TFatS. The BRAC1 relevant protein‑protein interaction networks (PPI) were fixed by STRING and visualized by CytoScape. Overall, the upregulated DEGs, which included CR2, IGHM, PRKCB, CARD11, PLCG2, CD79A, IGKC and CD27, were primarily enriched in the terms associated with immune responses, and the downregulated DEGs, which included STARD3, ALDH8A1, SRD5A3, CACNA1H, UGT2B4, SDR16C5 and MED1, were primarily enriched in the hormone metabolic process. In addition, 13 pathways, such as the B‑cell receptor‑signaling pathway, the hormone synthesis signaling pathway and the oxytocin‑signaling pathway, were chosen. MYC, SP1 and CTNNB1 were determined to be enriched in triple‑negative breast cancer. A total of 8 genes were identified to be downregulated in the BRAC1‑related PPI network. The results of the present study show a fresh angle on the molecular mechanism of triple‑negative breast cancer and indicate a possible target for its treatment.
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1 

Chu J, Bae H, Seo Y, Cho SY, Kim SH and Cho EY: The prognostic impact of synchronous ipsilateral multiple breast cancer: Survival Outcomes according to the Eighth American Joint Committee on cancer staging and molecular subtype. J Pathol Transl Med. 52:396–403. 2018. View Article : Google Scholar : PubMed/NCBI

2 

Perou CM, Sørlie T, Eisen MB, van de Rijn M, Jeffrey SS, Rees CA, Pollack JR, Ross DT, Johnsen H, Akslen LA, et al: Molecular portraits of human breast tumours. Nature. 406:747–752. 2000. View Article : Google Scholar : PubMed/NCBI

3 

Zubeda S, Kaipa PR, Shaik NA, Mohiuddin MK, Vaidya S, Pavani B, Srinivasulu M, Latha MM and Hasan Q: Her-2/neu status: A neglected marker of prognostication and management of patients with breast cancer in India. Asian Pac J Cancer Prev. 14:2231–2235. 2013. View Article : Google Scholar : PubMed/NCBI

4 

Bauer KR, Brown M, Cress RD, Parise CA and Caggiano V: Descriptive analysis of estrogen receptor (ER)-negative, progesterone receptor (PR)-negative, and HER2-negative invasive breast cancer, the so-called triple-negative phenotype: A population-based study from the California cancer Registry. Cancer. 109:1721–1728. 2010. View Article : Google Scholar

5 

Haque R, Ahmed SA, Inzhakova G, Shi J, Avila C, Polikoff J, Bernstein L, Enger SM and Press MF: Impact of breast cancer subtypes and treatment on survival: An analysis spanning two decades. Cancer Epidemiol Biomarkers Prev. 21:1848–1855. 2012. View Article : Google Scholar : PubMed/NCBI

6 

Carey LA, Perou CM, Livasy CA, Dressler LG, Cowan D, Conway K, Karaca G, Troester MA, Tse CK, Edmiston S, et al: Race, breast cancer subtypes, and survival in the Carolina Breast Cancer Study. JAMA. 295:2492–2502. 2006. View Article : Google Scholar : PubMed/NCBI

7 

Bosch A, Eroles P, Zaragoza R, Viña JR and Lluch A: Triple-negative breast cancer: Molecular features, pathogenesis, treatment and current lines of research. Cancer Treat Rev. 36:206–215. 2010. View Article : Google Scholar : PubMed/NCBI

8 

Stratton MR, Campbell PJ and Futreal PA: The cancer genome. Nature. 458:719–724. 2009. View Article : Google Scholar : PubMed/NCBI

9 

Lanza G, Ferracin M, Gafà R, Veronese A, Spizzo R, Pichiorri F, Liu CG, Calin GA, Croce CM and Negrini M: mRNA/microRNA gene expression profile in microsatellite unstable colorectal cancer. Mol Cancer. 6:542007. View Article : Google Scholar : PubMed/NCBI

10 

Jones S, Zhang X, Parsons DW, Lin JC, Leary RJ, Angenendt P, Mankoo P, Carter H, Kamiyama H, Jimeno A, et al: Core signaling pathways in human pancreatic cancers revealed by global genomic analyses. Science. 321:1801–1806. 2008. View Article : Google Scholar : PubMed/NCBI

11 

Lustig B and Behrens J: The Wnt signaling pathway and its role in tumor development. J Cancer Res Clin Oncol. 129:199–221. 2003.PubMed/NCBI

12 

Cancer Genome Atlas Network: Comprehensive molecular portraits of human breast tumours. Nature. 490:61–70. 2012. View Article : Google Scholar : PubMed/NCBI

13 

Wang X and Sommer RJ: Antagonism of LIN-17/Frizzled and LIN-18/Ryk in nematode vulva induction reveals evolutionary alterations in core developmental pathways. PLoS Biol. 9:e10011102011. View Article : Google Scholar : PubMed/NCBI

14 

Williams CB, Soloff AC, Ethier S and Yeh ES: Perspectives on epidermal growth factor receptor regulation in triple-negative breast cancer: Ligand-mediated mechanisms of receptor regulation and potential for clinical targetin. Adv Cancer Res. 127:253–281. 2015. View Article : Google Scholar : PubMed/NCBI

15 

Tao JJ, Castel P, Radosevic-Robin N, Elkabets M, Auricchio N, Aceto N, Weitsman G, Barber P, Vojnovic B, Ellis H, et al: Antagonism of EGFR and HER3 enhances the response to inhibitors of the PI3K-Akt pathway in triple-negative breast cancer. Sci Signal. 7:ra292014. View Article : Google Scholar : PubMed/NCBI

16 

Duncan JS, Whittle MC, Nakamura K, Abell AN, Midland AA, Zawistowski JS, Johnson NL, Granger DA, Jordan NV, Darr DB, et al: Dynamic reprogramming of the kinome in response to targeted MEK inhibition in triple-negative breast cancer. Cell. 149:307–321. 2012. View Article : Google Scholar : PubMed/NCBI

17 

Lee J, Galloway R, Grandjean G, Jacob J, Humphries J, Bartholomeusz C, Goodstal S, Lim B, Bartholomeusz G, Ueno NT and Rao A: Comprehensive two- and three-dimensional RNAi screening identifies PI3K inhibition as a complement to MEK inhibitor AS703026 for combination treatment of triple-negative breast cancer. J Cancer. 6:1306–1319. 2015. View Article : Google Scholar : PubMed/NCBI

18 

Kim S, Lee J, Jeon M, Lee JE and Nam SJ: MEK-dependent IL-8 induction regulates the invasiveness of triple-negative breast cancer cells. Tumour Biol. 37:4991–4999. 2016. View Article : Google Scholar : PubMed/NCBI

19 

Aksamitiene E, Kiyatkin A and Kholodenko BN: Cross-talk between mitogenicRas/MAPK and survival PI3K/Akt pathways: A fine balance. Biochem Soc Trans. 40:139–146. 2012. View Article : Google Scholar : PubMed/NCBI

20 

Fruman DA and Rommel C: PI3K and cancer: Lessons, challenges and opportunities. Nat Rev Drug Discov. 13:140–156. 2014. View Article : Google Scholar : PubMed/NCBI

21 

Ganesan P, Moulder S, Lee JJ, Janku F, Valero V, Zinner RG, Naing A, Fu S, Tsimberidou AM, Hong D, et al: Triple-negative patients with breast cancer treated at MD Anderson cancer center in phase I trials: Improved outcomes with combination chemotherapy and targeted agents. Mol Cancer Ther. 13:3175–3184. 2014. View Article : Google Scholar : PubMed/NCBI

22 

Juvekar A, Burga LN, Hu H, Lunsford EP, Ibrahim YH, Balmañà J, Rajendran A, Papa A, Spencer K, Lyssiotis CA, et al: Combining a PI3K inhibitor with a PARP inhibitor provides an effective therapy for BRCA1-related breast cancer. Cancer Discov. 2:1048–1063. 2012. View Article : Google Scholar : PubMed/NCBI

23 

Murai J, Huang SN, Das BB, Renaud A, Zhang Y, Doroshow JH, Ji J, Takeda S and Pommier Y: Trapping of PARP1 and PARP2 by clinical PARP inhibitors. Cancer Res. 72:5588–5599. 2012. View Article : Google Scholar : PubMed/NCBI

24 

Paul A and Paul S: The breast cancer susceptibility genes (BRCA) in breast and ovarian cancers. Front Biosci (Landmark Ed). 19:605–618. 2014. View Article : Google Scholar : PubMed/NCBI

25 

Tischkowitz MD and Foulkes WD: The basal phenotype of BRCA1-related breast cancer: Past, present and future. Cell Cycle. 5:963–967. 2006. View Article : Google Scholar : PubMed/NCBI

26 

He BS, Pan YQ, Lin K, Ying HQ, Wang F, Deng QW, Sun HL, Gao TY and Wang SK: Evaluation the susceptibility of five polymorphisms in microRNA-binding sites to female breast cancer risk in Chinese population. Gene. 573:160–165. 2015. View Article : Google Scholar : PubMed/NCBI

27 

Zhang L, Fang C, Xu X, Li A, Cai Q and Long X: Androgen receptor, EGFR, and BRCA1 as biomarkers in triple-negative breast cancer: A meta-analysis. Biomed Res Int. 2015:3574852015.PubMed/NCBI

28 

Sankpal UT, Goodison S, Abdelrahim M and Basha R: Targeting Sp1 transcription factors in prostate cancer therapy. Med Chem. 7:518–525. 2011. View Article : Google Scholar : PubMed/NCBI

29 

Tomlins SA, Rhodes DR, Perner S, Dhanasekaran SM, Mehra R, Sun XW, Varambally S, Cao X, Tchinda J, Kuefer R, et al: Recurrent fusion of TMPRSS2 and ETS transcription factor genes in prostate cancer. Science. 310:644–648. 2005. View Article : Google Scholar : PubMed/NCBI

30 

Yang Y, Goldstein BG, Chao HH and Katz JP: KLF4 and KLF5 regulate proliferation, Apoptosis and invasion in esophageal cancer cells. Cancer Biol Ther. 4:1216–1221. 2005. View Article : Google Scholar : PubMed/NCBI

31 

Yang L, Wu X, Wang Y, Zhang K, Wu J, Yuan YC, Deng X, Chen L, Kim CC, Lau S, et al: FZD7 has a critical role in cell proliferation in triple negative breast cancer. Oncogene. 30:4437–4446. 2011. View Article : Google Scholar : PubMed/NCBI

32 

Tusher VG, Tibshirani R and Chu G: Significance analysis of microarrays applied to the ionizing radiation response. Proc Natl Acad Sci USA. 98:5116–5121. 2001. View Article : Google Scholar : PubMed/NCBI

33 

Huang da W, Sherman BT and Lempicki RA: Systematic and integrative analysis of large gene lists using DAVID bioinformatics resources. Nat Protoc. 4:44–57. 2008. View Article : Google Scholar

34 

Essaghir A, Toffalini F, Knoops L, Kallin A, van Helden J and Demoulin JB: Transcription factor regulation can be accurately predicted from the presence of target gene signatures in microarray gene expression data. Nucleic Acids Res. 38:e1202010. View Article : Google Scholar : PubMed/NCBI

35 

von Mering C, Huynen M, Jaeggi D, Schmidt S, Bork P and Snel B: STRING: A database of predicted functional associations between proteins. Nucleic Acids Res. 31:258–261. 2003. View Article : Google Scholar : PubMed/NCBI

36 

Siegel RL, Miller KD and Jemal A: Cancer statistics, 2016. CA Cancer J Clin. 66:7–30. 2016. View Article : Google Scholar : PubMed/NCBI

37 

Fan L, Strasser-Weippl K, Li JJ, St Louis J, Finkelstein DM, Yu KD, Chen WQ, Shao ZM and Goss PE: Breast cancer in China. Lancet Oncol. 15:e279–e289. 2014. View Article : Google Scholar : PubMed/NCBI

38 

Fearon DT and Carter RH: The CD19/CR2/TAPA-1 complex of B lymphocytes: Linking natural to acquired immunity. Annu Rev Immunol. 13:127–149. 1995. View Article : Google Scholar : PubMed/NCBI

39 

Donius LR and Weis JH: Quantification of complement receptor 2 calcium signaling enhancement using flow cytometry. Methods Mol Biol. 1100:311–317. 2014. View Article : Google Scholar : PubMed/NCBI

40 

Kataoka K, Iwanaga M, Yasunaga JI, Nagata Y, Kitanaka A, Kameda T, Yoshimitsu M, Shiraishi Y, Sato-Otsubo A, Sanada M, et al: Prognostic relevance of integrated genetic profiling in adult T-cell leukemia/lymphoma. Blood. 131:215–225. 2018. View Article : Google Scholar : PubMed/NCBI

41 

Singh S, Arcaroli J, Thompson DC, Messersmith W and Vasiliou V: Acetaldehyde and retinaldehyde-metabolizing enzymes in colon and pancreatic cancers. Adv Exp Med Biol. 815:281–294. 2015. View Article : Google Scholar : PubMed/NCBI

42 

Uemura M, Tamura K, Chung S, Honma S, Okuyama A, Nakamura Y and Nakagawa H: Novel 5 alpha-steroid reductase (SRD5A3, type-3) is overexpressed in hormone-refractoryprostate cancer. Cancer Sci. 99:81–86. 2008.PubMed/NCBI

43 

Vogelstein B and Kinzler KW: Cancer genes and the pathways they control. Nat Med. 10:789–799. 2004. View Article : Google Scholar : PubMed/NCBI

44 

Chung HJ, Chi HS, Cho YU, Lee EH, Jang S, Park CJ and Seo EJ: Prognostic effect of cytoplasmic CD79a expression in acute myeloid leukemia with t(8;21). Korean J Lab Med. 27:388–393. 2007.(In Korean). View Article : Google Scholar : PubMed/NCBI

45 

Berahovich R, Xu S, Zhou H, Harto H, Xu Q, Garcia A, Liu F, Golubovskaya VM and Wu L: FLAG-tagged CD19-specific CAR-T cells eliminate CD19-bearing solid tumor cells in vitro and in vivo. Front Biosci (Landmark Ed). 22:1644–1654. 2017. View Article : Google Scholar : PubMed/NCBI

46 

Bednar KJ, Shanina E, Ballet R, Connors EP, Duan S, Juan J, Arlian BM, Kulis MD, Butcher EC, Fung-Leung WP, et al: Human CD22 inhibits murine B cell receptor activation in a human CD22 transgenic mouse model. J Immunol. 199:3116–3128. 2017. View Article : Google Scholar : PubMed/NCBI

47 

Yang Y, Gao M, Lin Z, Chen L, Jin Y, Zhu G, Wang Y and Jin T: DEK promoted EMT and angiogenesis through regulating PI3K/AKT/mTOR pathway in triple-negative breast cancer. Oncotarget. 8:98708–98722. 2017.PubMed/NCBI

48 

Szewczyk B, Pochwat B, Rafało A, Palucha-Poniewiera A, Domin H and Nowak G: Activation of mTOR dependent signaling pathway is a necessary mechanism of antidepressant-like activity of zinc. Neuropharmacology. 99:517–526. 2015. View Article : Google Scholar : PubMed/NCBI

49 

Wong VKW, Zeng W, Chen J, Yao XJ, Leung ELH, Wang QQ, Chiu P, Ko BCB and Law BYK: Tetrandrine, an activator of autophagy, induces autophagic cell death via PKC-α inhibition and mTOR-dependent mechanisms. Front Pharmacol. 8:3512017. View Article : Google Scholar : PubMed/NCBI

50 

Darnell JE Jr: Transcription factors as targets for cancer therapy. Nat Rev Cancer. 2:740–749. 2002. View Article : Google Scholar : PubMed/NCBI

51 

O'neill LA and Kaltschmidt C: NF-κB: A crucial transcription factor for glial and neuronal cell function. Trends Neurosci. 20:252–258. 1997. View Article : Google Scholar : PubMed/NCBI

52 

Barnes PJ: Nuclear factor-kappa B. Int J Biochem Cell Biol. 29:867–870. 1997. View Article : Google Scholar : PubMed/NCBI

53 

Zhu X, Mao Z, Na Y, Guo Y, Wang X and Xin D: Significance of pituitary tumor transforming gene 1 (PTTG1) in prostate cancer. Anticancer Res. 26:1253–1259. 2006.PubMed/NCBI

54 

Gorynia S, Bandeiras TM, Pinho FG, McVey CE, Vonrhein C, Round A, Svergun DI, Donner P, Matias PM and Carrondo MA: Structural and functional insights into a dodecameric molecular machine-the RuvBL1/RuvBL2 complex. J Struct Biol. 176:279–291. 2011. View Article : Google Scholar : PubMed/NCBI

55 

Bièche I, Laurendeau I, Tozlu S, Olivi M, Vidaud D, Lidereau R and Vidaud M: Quantitation of MYC gene expression in sporadic breast tumors with a real-time reverse transcription-PCR assay. Cancer Res. 59:2759–2765. 1999.PubMed/NCBI

56 

Le Floch N, Rivat C, De Wever O, Bruyneel E, Mareel M, Dale T and Gespach C: The proinvasive activity of Wnt-2 is mediated through a noncanonical Wnt pathway coupled to GSK-3beta and c-Jun/AP-1 signaling. FASEB J. 19:144–146. 2005. View Article : Google Scholar : PubMed/NCBI

57 

Chang KY, Huang CT, Hsu TI, Hsu CC, Liu JJ, Chuang CK, Hung JJ, Chang WC, Tsai KK and Chuang JY: Stress stimuli induce cancer-stemness gene expression via Sp1 activation leading to therapeutic resistance in glioblastoma. Biochem Biophys Res Commun. 493:14–19. 2017. View Article : Google Scholar : PubMed/NCBI

58 

Shibata T and Aburatani H: Exploration of liver cancer genomes. Nat Rev Gastroenterol Hepatol. 11:340–349. 2014. View Article : Google Scholar : PubMed/NCBI

59 

Lim E, Vaillant F, Wu D, Forrest NC, Pal B, Hart AH, Asselin-Labat ML, Gyorki DE, Ward T, Partanen A, et al: Aberrant luminal progenitors as the candidate target population for basal tumor development in BRCA1 mutation carriers. Nat Med. 15:907–913. 2009. View Article : Google Scholar : PubMed/NCBI

60 

Azariadis K, Kiagiadaki F, Pelekanou V, Bempi V, Alexakis K, Kampa M, Tsapis A, Castanas E and Notas G: Androgen triggers the pro-migratory CXCL12/CXCR4 axis in AR-positive breast cancer cell lines: Underlying mechanism and possible implications for the use of aromatase inhibitors in breast cancer. Cell Physiol Biochem. 44:66–84. 2017. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Qi F, Qin WX and Zang YS: Molecular mechanism of triple‑negative breast cancer‑associated BRCA1 and the identification of signaling pathways. Oncol Lett 17: 2905-2914, 2019.
APA
Qi, F., Qin, W., & Zang, Y. (2019). Molecular mechanism of triple‑negative breast cancer‑associated BRCA1 and the identification of signaling pathways. Oncology Letters, 17, 2905-2914. https://doi.org/10.3892/ol.2019.9884
MLA
Qi, F., Qin, W., Zang, Y."Molecular mechanism of triple‑negative breast cancer‑associated BRCA1 and the identification of signaling pathways". Oncology Letters 17.3 (2019): 2905-2914.
Chicago
Qi, F., Qin, W., Zang, Y."Molecular mechanism of triple‑negative breast cancer‑associated BRCA1 and the identification of signaling pathways". Oncology Letters 17, no. 3 (2019): 2905-2914. https://doi.org/10.3892/ol.2019.9884
Copy and paste a formatted citation
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Spandidos Publications style
Qi F, Qin WX and Zang YS: Molecular mechanism of triple‑negative breast cancer‑associated BRCA1 and the identification of signaling pathways. Oncol Lett 17: 2905-2914, 2019.
APA
Qi, F., Qin, W., & Zang, Y. (2019). Molecular mechanism of triple‑negative breast cancer‑associated BRCA1 and the identification of signaling pathways. Oncology Letters, 17, 2905-2914. https://doi.org/10.3892/ol.2019.9884
MLA
Qi, F., Qin, W., Zang, Y."Molecular mechanism of triple‑negative breast cancer‑associated BRCA1 and the identification of signaling pathways". Oncology Letters 17.3 (2019): 2905-2914.
Chicago
Qi, F., Qin, W., Zang, Y."Molecular mechanism of triple‑negative breast cancer‑associated BRCA1 and the identification of signaling pathways". Oncology Letters 17, no. 3 (2019): 2905-2914. https://doi.org/10.3892/ol.2019.9884
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