Open Access

Establishment of multiple diagnosis models for colorectal cancer with artificial neural networks

  • Authors:
    • Qiang Wang
    • Jianchang Wei
    • Zhuanpeng Chen
    • Tong Zhang
    • Junbin Zhong
    • Bingzheng Zhong
    • Ping Yang
    • Wanglin Li
    • Jie Cao
  • View Affiliations

  • Published online on: February 4, 2019     https://doi.org/10.3892/ol.2019.10010
  • Pages: 3314-3322
  • Copyright: © Wang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

The current study aimed to develop multiple diagnosis models for colorectal cancer (CRC) based on data from The Cancer Genome Atlas database and analysis with artificial neural networks in order to enhance CRC diagnosis methods. A genetic algorithm and mean impact value were used to select genes to be used as numerical encoded parameters to reflect cancer metastasis or aggression. Back propagation and learning vector quantization neural networks were used to build four diagnosis models: Cancer/Normal, M0/M1, carcinoembryonic antigen (CEA) <5/≥5 and Clinical stage I‑II/III‑IV. The performance of each model was evaluated by predictive accuracy (ACC), the area under the receiver operating characteristic curve (AUC) and a 10‑fold cross‑validation test. The ACC and AUC of the Cancer/Normal, M0/M1, CEA and Clinical stage models were 100%, 1.000; 87.14%, 0.670; 100%, 1.000; and 100%, 1.000, respectively. The 10‑fold cross‑validation test of the ACC values and sensitivity for each test were 93.75‑99.39%, 1.0000; 80.58‑88.24%, 0.9286‑1.0000; 67.21‑92.31%, 0.7091‑1.0000; and 59.13‑68.85%, 0.6017‑0.6585, respectively. The diagnosis models developed in the current study combined gene expression profiling data and artificial intelligence algorithms to create tools for improved diagnosis of CRC.
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March-2019
Volume 17 Issue 3

Print ISSN: 1792-1074
Online ISSN:1792-1082

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Copy and paste a formatted citation
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Spandidos Publications style
Wang Q, Wei J, Chen Z, Zhang T, Zhong J, Zhong B, Yang P, Li W and Cao J: Establishment of multiple diagnosis models for colorectal cancer with artificial neural networks. Oncol Lett 17: 3314-3322, 2019
APA
Wang, Q., Wei, J., Chen, Z., Zhang, T., Zhong, J., Zhong, B. ... Cao, J. (2019). Establishment of multiple diagnosis models for colorectal cancer with artificial neural networks. Oncology Letters, 17, 3314-3322. https://doi.org/10.3892/ol.2019.10010
MLA
Wang, Q., Wei, J., Chen, Z., Zhang, T., Zhong, J., Zhong, B., Yang, P., Li, W., Cao, J."Establishment of multiple diagnosis models for colorectal cancer with artificial neural networks". Oncology Letters 17.3 (2019): 3314-3322.
Chicago
Wang, Q., Wei, J., Chen, Z., Zhang, T., Zhong, J., Zhong, B., Yang, P., Li, W., Cao, J."Establishment of multiple diagnosis models for colorectal cancer with artificial neural networks". Oncology Letters 17, no. 3 (2019): 3314-3322. https://doi.org/10.3892/ol.2019.10010