Open Access

Vitamin D receptor polymorphisms and melanoma (Review)

  • Authors:
    • Alina F. Vasilovici
    • Lavinia Elena Grigore
    • Loredana Ungureanu
    • Oana Fechete
    • Elisabeta Candrea
    • Adrian P. Trifa
    • Simona Vișan
    • Simona Șenilă
    • Rodica Cosgarea
  • View Affiliations

  • Published online on: November 19, 2018     https://doi.org/10.3892/ol.2018.9733
  • Pages: 4162-4169
  • Copyright: © Vasilovici et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )


Abstract

Melanoma represents the most aggressive skin cancer, with an unpredictable and often treatment resistant behavior. The etiology of melanoma is multifactorial and includes both environmental and genetic factors. Recent evidence indicates that vitamin D has a role in the development and progression of melanoma. The biologically active form of vitamin D/1,25‑dihydroxyvitamin D3 acts by binding to a intranuclear receptor; vitamin D receptor (VDR). Single nucleotide polymorphisms (SNPs) in the vitamin D receptor gene may alter the expression or the function of the VDR protein leading to various diseases, including melanoma. More than 600 SNPs have been identified in the VDR gene, but only a few have been analyzed in relation to melanoma risk: FokI, TaqI, BsmI, ApaI, Cdx2, EcoRV, and BglI. Individual studies carried on small cohorts of patients reported controversial results. In an attempt to clarify the available data in the literature on this subject, we elaborated a systematic review in which we analyzed the relationship between VDR gene polymorphisms and melanoma risk and progression. We concluded that vitamin D pathway is important for the pathogenesis and the progression of cutaneous melanoma, illustrating the gene‑environment interactions, but well‑designed prospective studies that include data on both genotypes and phenotypes of vitamin D metabolism are essential in order to understand the mechanisms underlying the association between vitamin D and melanoma.
View References

Related Articles

Journal Cover

May-2019
Volume 17 Issue 5

Print ISSN: 1792-1074
Online ISSN:1792-1082

Sign up for eToc alerts

Recommend to Library

Copy and paste a formatted citation
x
Spandidos Publications style
Vasilovici AF, Grigore LE, Ungureanu L, Fechete O, Candrea E, Trifa AP, Vișan S, Șenilă S and Cosgarea R: Vitamin D receptor polymorphisms and melanoma (Review). Oncol Lett 17: 4162-4169, 2019
APA
Vasilovici, A.F., Grigore, L.E., Ungureanu, L., Fechete, O., Candrea, E., Trifa, A.P. ... Cosgarea, R. (2019). Vitamin D receptor polymorphisms and melanoma (Review). Oncology Letters, 17, 4162-4169. https://doi.org/10.3892/ol.2018.9733
MLA
Vasilovici, A. F., Grigore, L. E., Ungureanu, L., Fechete, O., Candrea, E., Trifa, A. P., Vișan, S., Șenilă, S., Cosgarea, R."Vitamin D receptor polymorphisms and melanoma (Review)". Oncology Letters 17.5 (2019): 4162-4169.
Chicago
Vasilovici, A. F., Grigore, L. E., Ungureanu, L., Fechete, O., Candrea, E., Trifa, A. P., Vișan, S., Șenilă, S., Cosgarea, R."Vitamin D receptor polymorphisms and melanoma (Review)". Oncology Letters 17, no. 5 (2019): 4162-4169. https://doi.org/10.3892/ol.2018.9733