Aspirin inhibits colon cancer cell line migration through regulating epithelial‑mesenchymal transition via Wnt signaling

  • Authors:
    • Shenghang Jin
    • Xianguo Wu
  • View Affiliations

  • Published online on: February 28, 2019     https://doi.org/10.3892/ol.2019.10089
  • Pages: 4675-4682
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Abstract

The mechanism responsible for the initiation of tumor metastasis and epithelial‑mesenchymal transition (EMT) is not well understood. During EMT, epithelial cells lose their polarity and adhesion to surrounding cells and migrate, resulting in transition into mesenchymal cells. Canonical Wnt signaling has been implicated in controlling gene transcription and body axis pattern formation during development. However, canonical Wnt signaling has also been indicated to serve a role in carcinogenesis by regulating EMT. In the present study, it was demonstrated that the expression of several positive regulators of EMT and Wnt signaling was repressed by aspirin treatment in SW480 tumor cells, and that this reduction was due to alterations in the localization of zinc finger E‑box binding homeobox 1 and Snail family transcriptional repressor 2. It was also demonstrated that aspirin may be an effective inhibitor of EMT, reducing the viability and migration ability of SW480 tumor cells, including cells induced by TGF‑β1.
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May-2019
Volume 17 Issue 5

Print ISSN: 1792-1074
Online ISSN:1792-1082

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Spandidos Publications style
Jin S and Jin S: Aspirin inhibits colon cancer cell line migration through regulating epithelial‑mesenchymal transition via Wnt signaling. Oncol Lett 17: 4675-4682, 2019
APA
Jin, S., & Jin, S. (2019). Aspirin inhibits colon cancer cell line migration through regulating epithelial‑mesenchymal transition via Wnt signaling. Oncology Letters, 17, 4675-4682. https://doi.org/10.3892/ol.2019.10089
MLA
Jin, S., Wu, X."Aspirin inhibits colon cancer cell line migration through regulating epithelial‑mesenchymal transition via Wnt signaling". Oncology Letters 17.5 (2019): 4675-4682.
Chicago
Jin, S., Wu, X."Aspirin inhibits colon cancer cell line migration through regulating epithelial‑mesenchymal transition via Wnt signaling". Oncology Letters 17, no. 5 (2019): 4675-4682. https://doi.org/10.3892/ol.2019.10089