Liver metastases from maxillary sinus sinonasal undifferentiated carcinoma: A case report

D'Aguanno,Vittorio; Ralli,Massimo; Cerbelli,Bruna; Greco,Antonio; de Vincentiis,Marco

doi:10.3892/ol.2019.10251

Liver metastases from maxillary sinus sinonasal undifferentiated carcinoma: A case report

Authors:
- Vittorio D'Aguanno
- Massimo Ralli
- Bruna Cerbelli
- Antonio Greco
- Marco de Vincentiis
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Affiliations: Department of Sense Organs, Sapienza University of Rome, I-00186 Rome, Italy, Department of Radiological Oncological and Pathological Sciences, Sapienza University of Rome, I-00186 Rome, Italy, Department of Oral and Maxillofacial Sciences, Sapienza University of Rome, I-00186 Rome, Italy
Published online on: April 15, 2019 https://doi.org/10.3892/ol.2019.10251
Pages: 5811-5814

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Abstract

Sinonasal undifferentiated carcinoma (SNUC) is a rare malignancy arising from the nasal cavity with neuroendocrine differentiation and aggressive behavior. When first diagnosed, SNUC is often locally advanced with nodal and distant metastases. The present study indicates a rare case of sole metastases to the liver from maxillary sinus undifferentiated carcinoma. Diagnosis was confirmed by total body computed tomography and immunohistochemical analysis on tissues from both maxillary and liver neoplastic tissues. SNUC is an aggressive malignancy characterized by a poor prognosis. Distant metastases commonly involve bones and lungs and should always be suspected in patients with locally advanced stages. Distant metastases can be found in unexpected organs due to dissemination via collateral venous plexuses; isolated liver metastatic disease may also occur. Although SNUC is considered a chemo‑sensitive malignancy, chemotherapy for metastatic SNUC needs to be further explored.

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