[Corrigendum] Inhibition of cyclooxygenase‑2 sensitizes lung cancer cells to radiation‑induced apoptosis

• Authors:
  • Zhi‑Qiang Han
  • Hongwei Liao
  • Feng Shi
  • Xiao‑Ping Chen
  • Hua‑Cheng Hu
  • Ming‑Qing Tian
  • Li‑Hua Wang
  • Songmin Ying

• View Affiliations

  
  Affiliations: Department of Respiratory Internal Medicine, People's Hospital of Quzhou City, Quzhou, Zhejiang 324000, P.R. China, Institute of Respiratory Diseases, Zhejiang University School of Medicine, Hangzhou, Zhejiang 310058, P.R. China, Department of Respiratory Internal Medicine, The Second Affiliated Hospital, Suzhou University, Suzhou, Jiangsu 215004, P.R. China
• Published online on: April 18, 2019     https://doi.org/10.3892/ol.2019.10268
• Pages: 5839-5840

• Copyright : © Han et al. This is an open access article distributed under the terms of Creative Commons Attribution License [CC BY 4.0].

Article

Oncol Lett 14: [Related article:] 5959-5965, 2017; DOI: 10.3892/ol.2017.6940

Following the publication of this article, the authors have realized that, owing to inadvertent errors during the preparation and revision of the manuscript, images were misplaced and mislabeled in Fig. 2B, and Table I contained erroneous information. Specifically, the ‘X-ray’ panel featured in Fig. 2B was selected incorrectly.

Figure 2. COX 2 inhibition increases the sensitivity of lung cancer cells to X-ray radiation. (A) Total RNA extract was amplified by reverse transcription-polymerase chain reaction and separated by agarose gel electrophoresis. Upper and lower lanes are COX-2 and β-actin, respectively. (B) Nuclear morphology of A549 cells treated with DMSO, X-rays, celecoxib or celecoxib plus X-rays. Nucleic changes, including anachromasis, pyknosis and karyorrhexis are indicated by the white arrows. Nuclei were stained with Hoechst 33258; image magnification, ×400. (C) A549 cells were irradiated with various doses of X-ray radiation, then treated with/without 200 μM celecoxib for three days. The growth inhibition curve is presented. Data are presented as the mean and standard error of five replicates. ****P<0.0001, two-way ANOVA. (D) Growth inhibition of A549 cells under indicated treatment. Data were pooled from three parallels and are presented as the mean ± standard deviation. Survival ratio at day 5 was subjected to statistical analysis. ****P<0.0001, two-way ANOVA. COX-2, cyclooxygenase-2; DMSO, dimethyl sulfoxide; ANOVA, analysis of variance.

Table I. Cell cycle analysis for each experimental group.

Table I.

Cell cycle analysis for each experimental group.

Group	Celexcoxib, µM	X-ray, Gy	G0/G1, %a	S, %a	G2/M, %a
Control	0	0	56.86±1.92	27.98±2.20	15.16±0.96
Celecoxib	50	0	74.38±2.16	14.67±1.75	10.95±0.48
	100	0	49.99±0.90	21.41±0.87	28.60±0.50
Radiation	0	6	54.62±1.49	18.55±0.93	26.83±0.77
Combination treatment	50	6	36.00±1.04	11.74±0.93	52.27±1.53
	100	6	29.20±0.34	12.60±0.10	58.20±0.36

a Data presented as mean ± standard deviation.

The corrected versions of Table I and Fig. 2, featuring all the correct data panels in Fig. 2B, are shown on the next page. These errors did not have an impact on the description, interpretation, or the original conclusions of the manuscript. The authors regret that these errors were allowed to enter into the published version of this article, and apologize to the readership for the inconvenience caused.