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Oncology Letters
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Print ISSN: 1792-1074 Online ISSN: 1792-1082
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September-October 2011 Volume 2 Issue 5

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International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

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Medicine International

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Article

Basic fibroblast growth factor induces cholangiocarcinoma cell migration via activation of the MEK1/2 pathway

  • Authors:
    • Siriluck Narong
    • Kawin Leelawat

  • View Affiliations / Copyright

    Affiliations: Division of Research and Technology Assessment, Department of Academic Support, Rangsit University, Bangkok, Thailand, Department of Surgery, Rajavithi Hospital, Bangkok 10400, Thailand
  • Pages: 821-825
    |
    Published online on: June 29, 2011
       https://doi.org/10.3892/ol.2011.333
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Abstract

The purpose of this study was to investigate the roles played by basic fibroblast growth factor (bFGF) in the induction of cholangiocarcinoma cell progression and to identify the signal transduction molecules that are activated by bFGF in cholangiocarcinoma cells. FGF receptor-2 (FGFR2) was shown to be expressed in two cholangiocarcinoma cell lines (RMCCA1 and KKU-100). Samples from RMCCA1 and KKU-100 were assayed for the mRNA. Phosphorylation levls were determined by Western blotting. Treatment of the cholangiocarcinoma cells with bFGF enhanced signaling via the phosphorylation of MEK1/2, induced cholangiocarcinoma cell migration and resulted in high levels of actin polymerization. Moreover, treatment with a MEK1/2 inhibitor (U0126) attenuated the effect of bFGF-induced cholangiocarcinoma cell migration. Taken together, these observations indicate that bFGF enhances the migration of cholangiocarcinoma cells and that this enhancement is regulated by the phosphorylation of MEK1/2.

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Copy and paste a formatted citation
Spandidos Publications style
Narong S and Leelawat K: Basic fibroblast growth factor induces cholangiocarcinoma cell migration via activation of the MEK1/2 pathway. Oncol Lett 2: 821-825, 2011.
APA
Narong, S., & Leelawat, K. (2011). Basic fibroblast growth factor induces cholangiocarcinoma cell migration via activation of the MEK1/2 pathway. Oncology Letters, 2, 821-825. https://doi.org/10.3892/ol.2011.333
MLA
Narong, S., Leelawat, K."Basic fibroblast growth factor induces cholangiocarcinoma cell migration via activation of the MEK1/2 pathway". Oncology Letters 2.5 (2011): 821-825.
Chicago
Narong, S., Leelawat, K."Basic fibroblast growth factor induces cholangiocarcinoma cell migration via activation of the MEK1/2 pathway". Oncology Letters 2, no. 5 (2011): 821-825. https://doi.org/10.3892/ol.2011.333
Copy and paste a formatted citation
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Spandidos Publications style
Narong S and Leelawat K: Basic fibroblast growth factor induces cholangiocarcinoma cell migration via activation of the MEK1/2 pathway. Oncol Lett 2: 821-825, 2011.
APA
Narong, S., & Leelawat, K. (2011). Basic fibroblast growth factor induces cholangiocarcinoma cell migration via activation of the MEK1/2 pathway. Oncology Letters, 2, 821-825. https://doi.org/10.3892/ol.2011.333
MLA
Narong, S., Leelawat, K."Basic fibroblast growth factor induces cholangiocarcinoma cell migration via activation of the MEK1/2 pathway". Oncology Letters 2.5 (2011): 821-825.
Chicago
Narong, S., Leelawat, K."Basic fibroblast growth factor induces cholangiocarcinoma cell migration via activation of the MEK1/2 pathway". Oncology Letters 2, no. 5 (2011): 821-825. https://doi.org/10.3892/ol.2011.333
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