Annexin A1, A2, A4 and A5 play important roles in breast cancer, pancreatic cancer and laryngeal carcinoma,alone and/or synergistically

Deng,Shishan; Wang,Jianguo; Hou,Lingmi; Li,Jinsui; Chen,Guo; Jing,Baoqian; Zhang,Xiaoming; Yang,Zhengwei

doi:10.3892/ol.2012.959

Annexin A1, A2, A4 and A5 play important roles in breast cancer, pancreatic cancer and laryngeal carcinoma,alone and/or synergistically

Authors:
- Shishan Deng
- Jianguo Wang
- Lingmi Hou
- Jinsui Li
- Guo Chen
- Baoqian Jing
- Xiaoming Zhang
- Zhengwei Yang
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Affiliations: Department of Anatomy, North Sichuan Medical College, Nanchong, P.R. China, Department of General Surgery, The Affiliated Hospital of North Sichuan Medical College, Nanchong, P.R. China, Institute of Immunology and Molecular Biology, North Sichuan Medical College, Nanchong, P.R. China, Sichuan Key Laboratory of Medical Imaging, North Sichuan Medical College, Nanchong, P.R. China, Morphometric Research Laboratory, North Sichuan Medical College, Nanchong, P.R. China
Published online on: October 9, 2012 https://doi.org/10.3892/ol.2012.959
Pages: 107-112

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Abstract

Annexins are associated with metastasis and infiltration of cancer cells. Proteomic analysis and immunohistochemical staining were used to understand whether several annexins play important roles in cancer alone and/or synergistically. Seven fresh breast cancer samples with 23 paraffin specimens, three fresh pancreatic samples and five fresh laryngeal carcinoma samples with 25 paraffin specimens were obtained from humans, as well as ten golden hamster pancreatic cancer tissue samples, and they were used to observe differential expression of annexins compared with normal tissues using proteomics and immunohistochemical staining. Annexin A2, A4 and A5 were overexpressed in human breast cancer and laryngeal carcinoma tissues and in golden hamster pancreatic cancer tissue samples, respectively, as shown by proteomics and immunohistochemical staining. In addition, annexin A4 and A5 were expressed in breast cancer tissues, while annexin A1 was not expressed. Annexin A1, A2 and A4 were expressed in human laryngeal carcinoma tissues as shown by immunohistochemical staining. Annexin A1, A2, A4 and A5 played important roles in breast cancer, pancreatic cancer and laryngeal carcinoma, alone and/or synergistically, and they may be targets of therapy for malignant tumors. The choice of which annexins to target should depend on their respective biological behaviors.

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1	Chuthapisith S, Bean BE, Cowley G, et al: Annexins in human breast cancer: Possible predictors of pathological response to neoadjuvant chemotherapy. Eur J Cancer. 45:1274–1281. 2009. View Article : Google Scholar : PubMed/NCBI
2	Lin LL, Chen CN, Lin WC, et al: Annexin A4: a novel molecular marker for gastric cancer with Helicobacter pylori infection using proteomics approach. Proteomics Clin Appl. 2:619–634. 2008. View Article : Google Scholar : PubMed/NCBI
3	Qi YJ, Wang LD, Jiao XY, et al: Dysregulation of annexin II expression in esophageal squamous cell cancer and adjacent tissues from a high-incidence area for esophageal cancer in Henan province. Ai Zheng. 26:730–736. 2007.(In Chinese).
4	Ji NY, Park MY, Kang YH, et al: Evaluation of annexin II as a potential serum marker for hepatocellular carcinoma using a developed sandwich ELISA method. Int J Mol Med. 24:765–771. 2009.PubMed/NCBI
5	Rodrigo JP, Garcia-Pedrero JM, Fernandez MP, Morgan RO, Suárez C and Herrero A: Annexin A1 expression in nasopharyngeal carcinoma correlates with squamous differentiation. Am J Rhinol. 9:483–587. 2005.PubMed/NCBI
6	Kim JK, Kim PJ, Jung KH, et al: Decreased expression of annexin A10 in gastric cancer and its overexpression in tumor cell growth suppression. Oncol Rep. 24:607–612. 2010.PubMed/NCBI
7	Gerke V and Moss SE: Annexins: from structure to function. Physiol Rev. 82:331–371. 2002.PubMed/NCBI
8	Deng S, Zhou H, Xiong R, et al: Over-expression of genes and proteins of ubiquitin specific peptidases (USPs) and proteasome subunits (PSs) in breast cancer tissue observed by the methods of RFDD-PCR and proteomics. Breast Cancer Res Treat. 104:21–30. 2007. View Article : Google Scholar : PubMed/NCBI
9	Marzook H, Li DQ, Nair VS, et al: Metastasis-associated protein 1 drives tumor cell migration and invasion through transcriptional repression of RING finger protein 144A. J Biol Chem. 287:5615–5626. 2012. View Article : Google Scholar
10	Singh RD, Haridas N, Patel JB, Shah FD, Shukla SN, Shah PM and Patel PS: Matrix metalloproteinases and their inhibitors: correlation with invasion and metastasis in oral cancer. Indian J Clin Biochem. 25:250–259. 2010. View Article : Google Scholar : PubMed/NCBI
11	Rohwer N, Lobitz S, Daskalow K, et al: HIF-1alpha determines the metastatic potential of gastric cancer cells. Br J Cancer. 100:772–781. 2009. View Article : Google Scholar : PubMed/NCBI
12	Yi S, Guangqi H and Guoli H: The association of the expression of MTA1, nm23H1 with the invasion, metastasis of ovarian carcinoma. Chin Med Sci J. 18:87–92. 2003.PubMed/NCBI
13	Wang KL, Wu TT, Resetkova E, et al: Expression of annexin A1 in esophageal and esophagogastric junction adenocarcinomas: association with poor outcome. Clin Cancer Res. 12:4598–4604. 2006. View Article : Google Scholar : PubMed/NCBI
14	Sharma M, Ownbey RT and Sharma MC: Breast cancer cell surface annexin II induces cell migration and neoangiogenesis via tPA dependent plasmin generation. Exp Mol Pathol. 88:278–286. 2010. View Article : Google Scholar : PubMed/NCBI
15	Inokuchi J, Narula N, Yee DS, Skarecky DW, Lau A, Ornstein DK and Tyson DR: Annexin A2 positively contributes to the malignant phenotype and secretion of IL-6 in DU145 prostate cancer cells. Int J Cancer. 124:68–74. 2009. View Article : Google Scholar : PubMed/NCBI
16	Moon HS, Lee YS and Chung HW: The annexin II expression in invasive cervical cancer. Korean J Gynecol Oncol. 18:8–16. 2007.
17	Huang Y, Jin Y, Yan CH, et al: Involvement of annexin A2 in p53 induced apoptosis in lung cancer. Mol Cell Biochem. 309:117–123. 2008. View Article : Google Scholar : PubMed/NCBI
18	Chan CM, Wong SC, Lam MY, et al: Proteomic comparison of nasopharyngeal cancer cell lines C666-1 and NP69 identifies down-regulation of annexin II and beta2-tubulin for nasopharyngeal carcinoma. Arch Pathol Lab Med. 2132:675–683. 2008.PubMed/NCBI
19	Duncan R, Carpenter B, Main LC, Telfer C and Murray GI: Characterisation and protein expression profiling of annexins in colorectal cancer. Br J Cancer. 98:426–433. 2008. View Article : Google Scholar : PubMed/NCBI
20	Xue G, Hao LQ, Ding FX, et al: Expression of annexin A5 is associated with higher tumor stage and poor prognosis in colorectal adenocarcinomas. J Clin Gastroenterol. 43:831–837. 2009. View Article : Google Scholar : PubMed/NCBI
21	Zhang J, Guo B, Zhang Y, Cao J and Chen T: Silencing of the annexin II gene down-regulates the levels of S100A10, c-Myc, and plasmin and inhibits breast cancer cell proliferation and invasion. Saudi Med J. 31:374–381. 2010.PubMed/NCBI
22	Alves VA, Nonogaki S, Cury PM, et al: Annexin A1 subcellular expression in laryngeal squamous cell carcinoma. Histopathology. 53:715–727. 2008. View Article : Google Scholar : PubMed/NCBI
23	Sitek B, Sipos B, Alkatout I, et al: Analysis of the pancreatic tumor progression by a quantitative proteomic approach and immunhistochemical validation. J Proteome Res. 8:1647–1656. 2009. View Article : Google Scholar : PubMed/NCBI