Portal vein tumor thrombus in advanced hepatocellular carcinoma: A case report

Chen,Xianli; Liu,Liguan; Pan,Xingnan

doi:10.3892/ol.2015.3115

Portal vein tumor thrombus in advanced hepatocellular carcinoma: A case report

Authors:
- Xianli Chen
- Liguan Liu
- Xingnan Pan
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Affiliations: Institute for Infectious Diseases, The 180th Hospital of The People's Liberation Army, Quanzhou, Fujian 362000, P.R. China
Published online on: April 14, 2015 https://doi.org/10.3892/ol.2015.3115
Pages: 2495-2498
Copyright: © Chen et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Portal vein tumor thrombus (PVTT) in hepatocellular carcinoma (HCC) is a common entity. However, the prognosis of patients with hepatocellular carcinoma (HCC) with portal vein tumor thrombus (PVTT) is extremely poor. The current study reports a case of HCC with PVTT, including a description of the gross surgical pathology and discussion of the relevance of assessing the growth of the tumor thrombus to the outcome of this disease. This case suggests that destruction of the primary tumor and PVTT must be considered according to the growth characteristics and modality of PVTT. It also indicates that transcatheter arterial embolization may be a suitable strategy for palliative treatment of patients with advanced HCC with PVTT.

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1	Montalto G, Cervello M, Giannitrapani L, Dantona F, Terranova A and Castagnetta LA: Epidemiology, risk factors, and natural history of hepatocellular carcinoma. Ann NY Acad Sci. 963:13–20. 2002. View Article : Google Scholar : PubMed/NCBI
2	Yamanaka N, Okamoto E, Fujihara S, et al: Do the tumor cells for hepatocellular carcinomas dislodge into the portal venous stream during hepatic resection? Cancer. 70:2263–2267. 1992. View Article : Google Scholar : PubMed/NCBI
3	Nakashima T and Kojiro M: Hepatocellular CarcinomaAn Atlas of Its Pathology. 7th. Springer Verlag; Tokyo: 1987
4	Wu MC, Chen H and Shen F: Surgical treatment of primary liver cancer: a report of 5524 patients. Chin J Surg. 39:25–28. 2001.
5	Zhang J, Gong F, Li L, et al: Diabetes mellitus and the neutrophil to lymphocyte ratio predict overall survival in non-viral hepatocellular carcinoma treated with transarterial chemoembolization. Oncol Lett. 7:1704–1710. 2014.PubMed/NCBI
6	Llovet JM, Bustamante J, Castells A, et al: Natural history of untreated nonsurgical hepatocellular carcinoma: rationale for the design and evaluation of therapeutic trials. Hepatology. 29:62–67. 1999. View Article : Google Scholar : PubMed/NCBI
7	Lau WY, Lai EC and Yu SCH: Management Of Portal Vein Tumor ThrombusHepatocellular Carcinoma. Lau WY: World Scientific Publishing; Singapore: pp. 739–760. 2008, View Article : Google Scholar
8	Pugh RNH, Murray-Lyon IM, Dawson JL, et al: Transection of the oesophagus for bleeding oesophageal varices. Br J Surg. 60:646–649. 1973. View Article : Google Scholar : PubMed/NCBI
9	Kamath PS, Wiesner RH, Malinchoc M, et al: A model to predict survival in patients with end-stage liver disease. Hepatology. 33:464–470. 2001. View Article : Google Scholar : PubMed/NCBI
10	Shuqun C, Mengchao W, Han C, et al: Tumor thrombus types influence the prognosis of hepatocellular carcinoma with the tumor thrombi in the portal vein. Hepatogastroenterology. 54:499–502. 2007.PubMed/NCBI
11	Shi J, Lai EC, Li N, et al: A new for classification hepatocellular carcinoma with portal vein tumor thrombus. J Hepatobiliary Pancreat Sci. 18:74–80. 2011. View Article : Google Scholar : PubMed/NCBI
12	Chen XP, Qiu FZ, Wu ZD, et al: Effects of location and extension of portal vein tumor thrombus on long-term outcomes of surgical treatment for hepatocellular carcinoma. Ann Surg Oncol. 13:940–946. 2006. View Article : Google Scholar : PubMed/NCBI
13	Bruix J and Sherman M: American Association for the Study of Liver Diseases: Management of hepatocellular carcinoma: an update. Hepatology. 53:1020–1022. 2011. View Article : Google Scholar : PubMed/NCBI
14	Arii S, Yamaoka Y, Futagawa S, et al: Results of surgical and nonsurgical treatment for small-sized hepatocellular carcinomas: A retrospective and nationwide survey in Japan. The Liver Cancer Study Group of Japan. Hepatology. 32:1224–1229. 2000. View Article : Google Scholar : PubMed/NCBI
15	Mazzaferro V, Regalia E, Doci R, et al: Liver transplantation for the treatment of small hepatocellular carcinomas in patients with cirrhosis. N Engl J Med. 334:693–699. 1996. View Article : Google Scholar : PubMed/NCBI
16	Kim DY, Park W, Lim DH, et al: Three-dimensional conformal radiotherapy for portal vein thrombosis of hepatocellular carcinoma. Cancer. 103:2419–2426. 2005. View Article : Google Scholar : PubMed/NCBI
17	Llovet JM and Bruix J: Systematic review of randomized trials for unresectable hepatocellular carcinoma: Chemoembolization improves survival. Hepatology. 37:429–442. 2003. View Article : Google Scholar : PubMed/NCBI
18	Bruix J, Sala M and Llovet JM: Chemoembolization for hepatocellular carcinoma. Gastroenterology. 127 (5 Suppl 1):S179–S188. 2004. View Article : Google Scholar : PubMed/NCBI
19	Lo CM, Ngan H, Tso WK, et al: Randomized controlled trial of transarterial lipiodol chemoembolization for unresectable hepatocellular carcinoma. Hepatology. 35:1164–1171. 2002. View Article : Google Scholar : PubMed/NCBI
20	Federico A, Orditura M, Cotticelli G, et al: Safety and efficacy of sorafenib in patients with advanced hepatocellular carcinoma and Child-Pugh A or B cirrhosis. Oncol Lett. 9:1628–1632. 2015.PubMed/NCBI