Oncology Letters Special Issues
Role of Wnt signaling pathway in lung cancer
Lead Editor:
-
Dr Noriaki Sunaga
Gunma University Graduate School of Medicine
Japan
The Wnt signaling pathway is classified into β-catenin-dependent (canonical) and -independent (non-canonical) pathways, both of which play pivotal roles in embryonic development and the regulation of many cellular functions. A close link between cancer and the canonical Wnt/β-catenin pathway has long been studied and growing evidence indicates that constitutive activation of the Wnt signaling by altered component of its pathway implicates in tumor growth, metastasis, angiogenesis, chromosome instability, cancer stemness, epithelial to mesenchymal transformation and immunomodulation of tumor microenvironment. Moreover, the Wnt pathway affects acquisition of resistance to molecular targeted drugs and immune checkpoint inhibitors. This special issue focuses on the role of Wnt signaling pathway in the tumorigenesis and therapeutic resistance in lung cancer.
Submission deadline: 22 June 2024
Natural Products: Recent Therapeutic Advances in Oncology Research
Lead Editor:
-
Professor Mourad A. M. Aboul-Soud
Chair of Medical and Molecular Genetics Research, Department of Clinical Laboratory Sciences, College of Applied Medical Sciences, King Saud University, P.O. Box 10219, Riyadh 11433
Saudi Arabia
Despite significant progress made towards discovery of potent chemotherapeutic agents, cancer remains an aggressive and devastating disease, being the second-leading cause of mortalities worldwide. Currently, therapeutic protocols employed to treat cancers primarily rely on three traditional strategies including surgery, chemotherapy and radiotherapy. The intrinsic non-target toxicity to normal cells of the repertoire of chemotherapeutic anticancer drugs utilized in clinical settings is considered a limitation. Alternatively, natural products (NPs) have been shown to be effective as anticancer drugs with a wider safety margin and minimal side effects. The primary focus of this special issue is therefore to invite submissions of original articles and reviews tackling the discovery of NPs isolated from various terrestrial and marine sources with potential anticancer activities and the elucidation of their mechanism-of-action. Studies employing in vitro cancer cell lines and in vivo non-human primate models are welcome provided that they are appropriately-designed to include non-cancerous and positive controls. Research on natural extracts/fractions must incorporate full chemical characterization of their constituents. Articles dealing with the cytotoxicity of green-synthesized nanoparticles such as metal, metal oxide and polymeric nanocomposites are also welcome contingent on including mechanistic insights. Work on naturally-derived synthetic analogues or congeners with enhanced efficacy is also considered.
Submission deadline: 01 August 2024
