MALIGNANT FIBROUS HISTIOCYTOMA OF THE SPLEEN - REPORT ON A CASE PRESENTING AS EMERGENCY

  • Authors:
    • GA DELGAUDIO
    • S PILERI
    • E SABATTINI
    • A DELGAUDIO
  • View Affiliations

  • Published online on: July 1, 1994     https://doi.org/10.3892/or.1.4.825
  • Pages: 825-829
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Abstract

Among the primary malignant tumours of the spleen, fibrous histiocytoma (MFH) is extremely rare and only six cases have been reported in the literature. A splenectomy was carried out in a 22-year-old woman presenting with an acute abdomen. Imaging procedures showed a 5 cm round, heterogeneous mass in the spleen. At light microscopy the infiltrating cell population was arranged in nests or bundles with a storiform pattern. At higher magnification, most neoplastic elements were medium-sized, round or spindle-shaped, with acidophilic cytoplasm and oval or round nucleus. Mitotic figures were numerous; reactive foamy macrophages could be seen. At immunohistochemistry, in paraffin sections, there was strong positivity with the reagents against CD45, CD68, alfa-1-antichymotrypsin and vimentin. In frozen sections there was a clear-cut positivity with the antibodies EBM11 (CD68), KP1 (CD68), Ber Mac 3, anti-lysozyme and anti-vimentin. The case reported revealed morphological and immunohistochemical features consistent with MFH, of the storiform-pleomorphic variant. The clear-cut positivity for macrophage-associated molecules and for leucocyte common antigen would seem to suggest a histiocytic origin. MFH is considered an aggressive tumour, with a frequent recurrence and metastasis but our patient is alive and free of disease three years from surgery.

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July 1994
Volume 1 Issue 4

Print ISSN: 1021-335X
Online ISSN:1791-2431

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APA
DELGAUDIO, G., PILERI, S., SABATTINI, E., & DELGAUDIO, A. (1994). MALIGNANT FIBROUS HISTIOCYTOMA OF THE SPLEEN - REPORT ON A CASE PRESENTING AS EMERGENCY. Oncology Reports, 1, 825-829. https://doi.org/10.3892/or.1.4.825
MLA
DELGAUDIO, G., PILERI, S., SABATTINI, E., DELGAUDIO, A."MALIGNANT FIBROUS HISTIOCYTOMA OF THE SPLEEN - REPORT ON A CASE PRESENTING AS EMERGENCY". Oncology Reports 1.4 (1994): 825-829.
Chicago
DELGAUDIO, G., PILERI, S., SABATTINI, E., DELGAUDIO, A."MALIGNANT FIBROUS HISTIOCYTOMA OF THE SPLEEN - REPORT ON A CASE PRESENTING AS EMERGENCY". Oncology Reports 1, no. 4 (1994): 825-829. https://doi.org/10.3892/or.1.4.825