Membranous lipodystrophy (Nasu-Hakola disease) presenting an unusually benign clinical course

  • Authors:
    • Kumiko Haruta
    • Shunji Matsunaga
    • Hiroshi Ito
    • Kyoji Hayashi
    • Masahiro Yokouchi
    • Toshiyuki Onishi
    • Setsuro Komiya
  • View Affiliations

  • Published online on: July 1, 2003     https://doi.org/10.3892/or.10.4.1007
  • Pages: 1007-1010
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Abstract

Membranous lipodystrophy is known as Nasu-Hakola disease. The main symptoms of membranous lipodystrophy are those of a progressive presenile dementia due to sclerosing leukoencephalopathy with skeletal polycystic lesions. There is no report detailing long-term follow-up of patients with membranous lipodystrophy. We present a 56-year-old woman with this disease who has not manifested any typical neuropsychiatric symptoms during the 16-year follow-up, and thus has had an unusually benign clinical course. The patient underwent curettage and bone grafts. Periodic examinations have been continued for 16 years from discharge. No recurrence of lesions or occurrence of new cystic lesions has been noted. Computerized tomography and magnetic resonance imaging of the brain revealed none of the abnormal change which are reported in this disease. Our findings suggest that some patients with this disease may be fortunate enough to follow a relatively benign clinical course.

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July-August 2003
Volume 10 Issue 4

Print ISSN: 1021-335X
Online ISSN:1791-2431

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Spandidos Publications style
Haruta K, Matsunaga S, Ito H, Hayashi K, Yokouchi M, Onishi T and Komiya S: Membranous lipodystrophy (Nasu-Hakola disease) presenting an unusually benign clinical course. Oncol Rep 10: 1007-1010, 2003
APA
Haruta, K., Matsunaga, S., Ito, H., Hayashi, K., Yokouchi, M., Onishi, T., & Komiya, S. (2003). Membranous lipodystrophy (Nasu-Hakola disease) presenting an unusually benign clinical course. Oncology Reports, 10, 1007-1010. https://doi.org/10.3892/or.10.4.1007
MLA
Haruta, K., Matsunaga, S., Ito, H., Hayashi, K., Yokouchi, M., Onishi, T., Komiya, S."Membranous lipodystrophy (Nasu-Hakola disease) presenting an unusually benign clinical course". Oncology Reports 10.4 (2003): 1007-1010.
Chicago
Haruta, K., Matsunaga, S., Ito, H., Hayashi, K., Yokouchi, M., Onishi, T., Komiya, S."Membranous lipodystrophy (Nasu-Hakola disease) presenting an unusually benign clinical course". Oncology Reports 10, no. 4 (2003): 1007-1010. https://doi.org/10.3892/or.10.4.1007